ABSTRACT
The aggressive tumour known as oral cancer can metastasize, produce a high fatality rate, and infect nearby tissue. Surgery, chemotherapy, and radiation therapy, for example, are common treatment options that, when used in clinical settings, have both minimal drawbacks and major side effects. Currently, oral therapeutic medication delivery using targeted drug administration is proving to be effective. In recent years, an effective alternative therapy known as “nanomedicine,” or using nanoplatforms to deliver drugs for the treatment of cancer, has evolved. Thanks to the use of nanoplatforms, drug delivery to the tumour site can be done precisely and with minimal drug degradation in the body. As a result, the drug's toxicity is diminished, its concentration at the tumour site is elevated, and its distribution to other organs is kept to minimum. We present a contemporary review of the development medication delivery targeted for the treatment of oral cancer in this article different oral delivery systems, including as cyclodextrins, liposomes, hydrogel-based forms, and nanolipids are highlighted and explored. Biomimetic systems, such as therapeutic vitamins, proteins, exosomes, and virus-like particles, with a focus on cancer treatment, are also described. The study concludes with a brief analysis of future applications for nanoplatforms in the treatment of oral cancer
ABSTRACT
The camps have been organized for rural cervical cancer screening in the villages of Lucknow which offer valuable platform for the detection of infertility in young women and their cytological examination. The cervical cytology has been studied in the cases of infertility to find out if there is any increase in abnormal cytology and compare them with those obtained in fertile women (controls).Since its inception in May 2013, the camps organized were 186 in number and 5682 women attended these camps. Primary infertility was found in 182 and the secondary infertility in 31 women. The incidence of Squamous intraepithelial lesions of cervix (SIL) was found to be 14.8% in women suffering from primary infertility and 16.1% in the secondary infertility cases and was comparable with SIL rate of 17.4% in the controls. Persistent vaginal infections caused by the poor personal genital hygiene practiced by the rural women may be the reason for a high SIL rate in the fertile women. The SIL rate was seen high in the younger women upto 30 years with pain in lower abdomen and erosion cervix in the primary infertility cases while the high SIL rate was seen in 21- 30 years age groups with parity 2 in secondary infertility cases with no SIL seen with symptoms and clinical lesions. Mostly young women upto 30 years of age complained of infertility and showed high SIL rate. These women were referred to the Hospital of Era Medical College, Lucknow for further investigation and treatment.
ABSTRACT
Various types of tumor markers are currently being investigated to ascertain their capability in discriminating pre-cancerous lesions of cervix who have tendency for progression. The adequate treatment of such cases will check any chances of occurrence of carcinoma cervix in the population. The micro- RNAs are sensitive tumor markers but their high cost and sophisticated technique make them not feasible to be introduced in any cervical cancer screening program under Indian setup. Other tumor markers like claudins, p16, Ki67 etc are also very expensive. AgNOR pleomorphic counts and micronuclei counts are cheaper, the farmer being more reliable can be introduced in cytological screening program to identify high risk cases and can easily replace costly Human papilloma virus (HPV)- DNA testing.
ABSTRACT
Cervical carcinoma is one of the most common and dreaded diseases of women, and in India, it accounts for 16 per cent of total cervical cancer cases occurring globally. The situation is more alarming in the rural areas where the majority of women are illiterate and ignorant about the hazards of cervical cancer. Different screening strategies such as rural cancer registries and camp approach for cancer detection have been found useful in minimizing the problem of cervical cancer in the villages. Various screening techniques such as visual inspection with acetic acid, visual inspection with Lugol's iodine, visual inspection with magnification devices-magnavisualizer, Pap smear and HPV-DNA testing have been suggested and tried under low-resource settings of our country, and cervical cytology screening has been found effective in reducing incidence of the disease. In the present review, feasibility of different screening methods has been assessed to find out the most suitable mode applicable at the rural level. Single lifetime screening particularly of high-risk women along with analysis of cost-effective tumour markers such as Argyrophilic nucleolar organizer regions (AgNOR) counts to discriminate high-risk dysplasia cases appears to be an appropriate approach in fighting against cervical cancer.