ABSTRACT
Objective: The aim of this study was to investigate the association between platelet-to-lymphocyte ratio [PLR] and atrial fibrillation [AF] after coronary artery bypass graft [CABG] surgery
Subjects and Methods: A total of 125 patients were retrospectively analyzed. AF was diagnosed using standard clinical criteria, and PLR was calculated as the ratio of the platelets to lymphocytes, obtained from the blood samples that were taken in the fasting state before CABG surgery. The association of different variables with postoperative AF and PLR was calculated using univariate and multivariate analysis. The receiver operating characteristics curve was used to determine the sensitivity and specificity of PLR and the optimal cutoff value for predicting post-CABG AF
Results: Of the 125 patients, 50 with AF [mean age: 67.0 +/- 9.5 years, 38 males and 12 females] and 75 patients without AF [mean age: 61.1 +/- 9.1 years, 58 males and 17 females] were identified, and the difference in the mean age was statistically significant [p = 0.01]. PLR was also significantly higher in those with AF [152.8 +/- 82.2] than those without AF [118.2 +/- 32.9] [p = 0.012]. Univariate analysis showed that age and PLR were associated with AF after CABG surgery [p < 0.001 and p = 0.005, respectively]. Using a multivariate logistic regression model with the backward elimination method, age and PLR remained as independent predictors of AF after CABG surgery [p < 0.001 and p = 0.005, respectively]. PLR levels >119.3 predicted postoperative AF with 64% sensitivity and 56% specificity [AUC: 0.634, p = 0.012]
Conclusion: In this study, age and PLR level were independent predictors of AF after CABG surgery. Patients with an elevated preoperative PLR were at higher risk of AF after CABG surgery
ABSTRACT
<p><b>BACKGROUND</b>Outcomes in patients requiring coronary artery bypass graft (CABG) surgery have been improved with devices such as the intra-aortic balloon pump (IABP). Good coronary collateral circulation (CCC) has been shown to reduce mortality in patients with coronary artery disease (CAD). We aimed to investigate whether poor preoperative CCC grade is a predictor of in-hospital mortality in CABG surgery requiring IABP support.</p><p><b>METHODS</b>Fifty-five consecutive patients who were undergoing isolated first time on-pump CABG surgery with IABP support were enrolled into this study and CCC of those patients was evaluated.</p><p><b>RESULTS</b>Twenty-seven patients had poor CCC and 28 patients had good CCC. In-hospital mortality rate in poor CCC group was significantly higher than good CCC group (14 (50%) vs. 4 (13%), P = 0.013). Preoperative hemoglobin level (OR: 0.752; 95% CI, 0.571-0.991, P = 0.043), chronic obstructive pulmonary disease (OR: 6.731; 95% CI, 1.159-39.085, P = 0.034) and poor CCC grade (OR: 5.750; 95% CI, 1.575±20.986, P = 0.008) were associated with post-CABG in-hospital mortality. Poor CCC grade (OR: 4.853; 95% CI, 1.124-20.952, P = 0.034) and preoperative hemoglobin level (OR: 0.624; 95% CI, 0.476-0.954, P = 0.026) were independent predictors of in-hospital mortality after CABG.</p><p><b>CONCLUSION</b>Preoperative poor CCC and hemoglobin are predictors of in-hospital mortality after CABG with IABP support.</p>