ABSTRACT
Background: breast carcinoma has been regarded as the most common malignant tumors and the leading cause of death due to cancer in women. Apoptosis plays a central role in both normal cell cycle and tumor biology; it is controlled by family of related proteins including Bax and bcl-2. This study was designed to evaluate the expression of Bax and bcl-2 proteins in 46 cases of Invasive-Ductal carcinoma of breast and their correlation to the expression of ki-67, estrogen and progesterone receptors immunohistochemically
Materials and methods: formalin fixed paraffin embedded-tissue from 46 cases of invasive ductal carcinoma of breast were analyzed by immunohistochimistry [IHC] method. We performed a statistical analysis to investigate the relationship between clinicopathological parameters and Bax, bcl-2, KI-67, ER. PR expressions
Results: forty-six cases of invasive ductal carcinoma of breast with mean age 45 were studied. According to Bloom-Richardson score system of 46 cases. 8.7% were grade 1 1.80% were grade 2 and 11% were grade 3. Eighty-seven percent of cases had 4 or more lymph node metastasis. According to IHC results, 43% were bcl 2 positive, 28% were ER positive, 39% were PR positive , and 95% were Bax positive ,mean KI-67 index was 40% . There was significant correlation between bcl-2 expression and ER, PR and size of tumor. There wasn't any correlation between Bax and PR and ER status .there was statistically correlation between KI-67 index and ER and PR status, grade and metastasis to lymph nodes .There was statically correlation between ER and PR status and size of tumor, grade and metastasis to lymph nodes
Conclusion: Bcl-2, as an anti-apoptotic factor, plays an important role in biology of breast cancer. It may be a mediator in the action of ER and PR or it may have independent role. KI-67 as a proliferative maker. doesn't have any correlation with apoptotic factors, but have prognostic valve through its relation to ER, PR. grade and LN status. Because of high rate of Bax positively, we guess IHC isn't a good way for evaluation of Bax and it is better to use molecular methods
ABSTRACT
The authors reported a case of mucoepidermoid carcinoma of esophagus, which is a rare primary carcinoma of the esophagus, characterized by a diffuse mixture of squamous and mucin-secreting glandular carcinoma cells. The patient was a 54-year-old man with a five-month history of dysphagia and endoscopic biopsy diagnosis of scc. The patient underwent a curative esophagectomy with a regional lymph node dissection. Histopathologic and histochemical study of specimen showed mucoepidermoid carcinoma of the esophagus