ABSTRACT
This work was conducted on pregnant and non pregnant rats aiming to study the effect of opiod agonists [Morphine and fentanyl] on blood picture and immune system. The pathological changes in liver, spleen and kidney that accomapany their administration were also studied in mothers as well as, their offsprings. The experiments were done after single and repeated administration It revealed that: i. Morphine has a toxic effect on the haemopioetic and immune systems and this effect depends on the dose and duration. ii. Fentanyl is more safe than mrorphine. iii. Pregnancy potentiates the effect of opioids. iv. The offsprings suffer from opiods more than mothers due to inadequancy of the enzyme system metabolising the drug. So, it is better to decrease the dose of opiods during labour and avoid any treatment containing opiods during pregnancy