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Indian J Physiol Pharmacol ; 1978 Jul-Sep; 22(3): 317-20
Article in English | IMSEAR | ID: sea-108636

ABSTRACT

Six basic amides were screened for local anaesthetic activity and compared with procaine and lignocaine. Amongst the basic amides screened, piperidino-N-(alpha-4-ethoxy phenyl- beta-phenyl) ethyl and Diethylamino-N (alpha-4-ethoxy- beta-phenyl) ethyl acetamide were found to be more effective as compared to lignocaine. They were found to be non-irritant, and non-toxic even in high doses.


Subject(s)
Acetamides/pharmacology , Anesthetics, Local , Animals , Guinea Pigs , Lethal Dose 50 , Lidocaine/pharmacology , Procaine/pharmacology , Rabbits
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