Effect of immune suppression on intestinal mastocytosis in experimental trichinosis

The present study showed that experimental Trichinella infection of rats resulted in marked mucosal mast cell hyperplasia among infected non-treated and Endoxan treated rats in comparison to non infected and hydrocortisone treated rats who showed non significant mucosal mast cell alteration. The present finding supports the view that the precursors of mucosal mast cells involved in Trichinella expulsion are T-lymphocyte dependent and be inhibited by cortisone therapy and not by cyclo- phosphamide