ABSTRACT
Some studies have determined that polymorphism in insulin gene are associated with increased insulin level and resistant to insulin and also cause to increase risk of colorectal cancer [CRC]. The goal of this study was to evaluate incidence of the insulin gene polymorphism [rs689] in an Iranian population and to investigate the role of this polymorphism in increased risk of CRC. Genotyping of the insulin gene were determined in a series of 110 colorectal cancer patients and 110 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays [PCR-RFLP]. P value for genotype AT compared with AA, was 0.052 [OR=1.88, CI=0.99-3.5] and TT versus AA was 0.57 [OR=1.33 CI=0.48- 3.6]. The results showed that the insulin gene polymorphism [rs689] is not a predisposing factor to increased risk to CRC [P=0.14]. Incidence of mutant allele between patients and controls had no significant differences [OR=1.53 95% CI=0.98- 2.39, Pe=0.057]. These findings suggest that the insulin gene polymorphism [rs689] is not associated with increased risk of CRC