Lipid profiles and lipoprotein [Lp a] levels of marasmic children: the influence of short rehabilitation

The biochemical changes of lipid me tabolism in marasmic children before and after nutritional treatment were evaluated in thirty patients with age ranging from 6 to 24 months. All subjects were submitted to anthropometric measurements, liver and kidney function tests, lipid profiles, lipoproteins and lipoprotein [a] [Lp[a]] levels. All studied parameters were repeated one month after nutritional therapy. The results showed significant increase in weight, midarm and chest circumferences of cases after nutritional therapy. No significant differences were detected in serum total protein, albumin, AST, ALT, urea and creatinine. The laboratory results of lipid profiles after treatment showed significant decrease of mean serum levels of total lipids and triglycerides, meanwhile mean levels of total cholesterol [TC], and lipoproteins [HDL-c, LDL-c and Lp [a]] were significantly elevated. The risk ratios TC/HDL-c and LDL/HDL-c were not changed significantly after treatment. Our results indicated that improvement of the studied anthropometric measurements in marasmic children after short dietatic therapy is attributed mainly to changes in lipid profiles and that diet has some influence on Lp [a] levels in those children

Comparison of glycosylated hemoglobin and serum fructosamine as an index of glycemic control in diabetic patients with chronic renal failure

This study aimed to compare between glycosylated hemoglobin HbA[IC] and fructosamine in diabetic patients with C.R.F. to determine which of them is more valid as an index for glycemic control. Our work was carried on five groups each consisted of twenty diabetic non-uremic [group I], diabetic uremic on regular hemodialysis [group II] diabetic uremic on conservative treatment [group III], uremic non diabetic on regular hemodialysis [group IV] and healthy control subjects [group Y]. All of them were investigated for total plasma protein, fasting and post prandial serum gluose, serum creatinine, hemoglobin content, HbA[IC] and serum fructosamine level. It was evident from his work that the level of both HbA[IC] and fructosamine was significantly higher in diabetic patients with and without uremia when compared to control group. Although HbA[IC] level was significantly low in uremic non-diabetic patients, serum fructosamine level didn't change significantly in these patients. This finding can be explained by the fact that the life span is shortened in uremic patients, while both parameters which affect serum fructosamine level [blood sugar and total protein] showed no significant alteration in these patients. A negative non-significant correlation was found between seum creanine and both HbA[IC] level and serum fuctosamine level among all studied. In all studied groups, plasma glucose [Fasting and post prandial] showed positive significant correlation with both glycosylated hemoglobin and serum fructosamine. HbA[IC] correlated significantly with Hb level, mean while serum fructosamine correlated significantly with total serum protein. We can conclude that serum fructosamine is the test of choice for judging the glycemic control in uremic patients, because it is not affected by uremia and because of its automaticity, reproducibility and cheapness