ABSTRACT
This study aimed at evaluating the effect of application of different patterns of positive ventilatory pressure either during or after cardiopulmonary bypass [CPB], on lung functions. 30 patients undergoing coronary artery revascularisation under the management of CPB were randomly allocated into 3 groups. Group I [VCM] 10 patients were subjected to manual vital capacity manoeuvre [VCM] before weaning off the CPB. Group II [CPAP] 10 patients were subjected to continuous positive airway pressure [CPAP] of 10 cm H[2]O during CPB. Group III [PEEP] 10 patients were subjected to positive end expiratory pressure [PEEP] of 7 cmH[2]O after weaning off the CPB. Measurements included the PO[2] PCO[2] together with derived calculated parameters as the alveolar-arterial oxygen difference [P [A-a] DO[2]] and shunt fraction, as welt as the dynamic lung compliance being recorded directly from the anesthetic and ventilatory equipments. All readings were taken on closed chest and on FiO[2] of 0.5. Intraoperative anesthetic and surgical data as well as postoperative extubation time and length of ICU stay were also evaluated. Statistical analysis of ventilatory parameters showed no significant differences for both PO[2] and PCO[2] in between the studied groups. Alveolar-Arterial oxygen difference mean values were comparable in the 3 studied groups. The mean values of intrapulmonary shunt fraction showed a significant difference in relation to the baseline values in Group I [VCM] and Group III [PEEP] at 30 minutes after ICU admission and 4 hours post CPB with estimated P value <0.01 and <0.05 respectively, while in Group II [CPAP] mean values started to be significant after chest closure with a P value <0.05, but there was no significant intergroup differences with a P value >0.01. Dynamic lung compliance mean values showed no intergroup statistical significance. Maintenance of ventilatory parameters was achieved in all the positive pressure ventilatory methods applied, either being applied during or after CPB