ABSTRACT
Metabolic syndrome (MBS) is a widespread disease that has strongly related to unhealthy diet and low physical activity, which initiate more serious conditions such as obesity, cardiovascular diseases and type 2 diabetes mellitus. This study aimed to examine the therapeutic effects of morin, as one of the flavonoids constituents, which widely exists in many herbs and fruits, against some metabolic and hepatic manifestations observed in MBS rats and the feasible related mechanisms. MBS was induced in rats by high fructose diet feeding for 12 weeks. Morin (30 mg/ kg) was administered orally to both normal and MBS rats for 4 weeks. Liver tissues were used for determination of liver index, hepatic expression of glucose transporter 2 (GLUT2) as well as both inflammatory and fibrotic markers. The fat/muscle ratio, metabolic parameters, systolic blood pressure, and oxidative stress markers were also determined. Our data confirmed that the administration of morin in fructose diet rats significantly reduced the elevated systolic blood pressure. The altered levels of metabolic parameters such as blood glucose, serum insulin, serum lipid profile, and oxidative stress markers were also reversed approximately to the normal values. In addition, morin treatment decreased liver index, serum liver enzyme activities, and fat/muscle ratio. Furthermore, morin relatively up-regulated GLUT2 expression, however, down-regulated NF-kB, TNF-β, and TGF-β expressions in the hepatic tissues. Here, we revealed that morin has an exquisite effect against metabolic disorders in the experimental model through, at least in part, antioxidant, anti-inflammatory, and anti-fibrotic mechanisms.
ABSTRACT
Background@#Inguinal hernia repair is one of the most commonly performed surgical procedures. Regional blocks might provide excellent analgesia and reduce complications in the postoperative period. We aimed to compare the postoperative analgesic effect of the ultrasound-guided transversalis fascia (TF) plane block versus the transmuscular quadratus lumborum (QL) block in patients undergoing unilateral inguinal hernia repair. @*Methods@#Fifty patients enrolled in this comparative study and were randomly assigned into two equal groups. One group received an ultrasound-guided QL block.In comparison, the other group received an ultrasound-guided TF plane block. The primary outcome was the patient-assessed resting, and movement-induced pain on the numeric pain rating scale (NRS) measured at 30 minutes postoperatively. Secondary outcomes included the percentage of patients receiving rescue analgesia in the first postoperative day, ease of performance of the technique, and incidence of adverse effects. @*Results@#There were no statistically significant differences in NRS at rest and with movement between the groups over the first 24 hours postoperatively. The proportion of patients that received postoperative rescue analgesics during the first 30 minutes postoperatively was 4% (n = 1) in the QL group compared to 12% (n = 3) in the TF group. However, the mean performance time of the TF block was shorter than that of the QL block, and the performance of the TF block appeared easier technically. @*Conclusions@#The ultrasound-guided TF plane block could be as effective as the QL block in lowering pain scores and decreasing opioid consumption following nonrecurrent inguinal herniorrhaphy.
ABSTRACT
Metabolic syndrome (MBS) is a widespread disease that has strongly related to unhealthy diet and low physical activity, which initiate more serious conditions such as obesity, cardiovascular diseases and type 2 diabetes mellitus. This study aimed to examine the therapeutic effects of morin, as one of the flavonoids constituents, which widely exists in many herbs and fruits, against some metabolic and hepatic manifestations observed in MBS rats and the feasible related mechanisms. MBS was induced in rats by high fructose diet feeding for 12 weeks. Morin (30 mg/ kg) was administered orally to both normal and MBS rats for 4 weeks. Liver tissues were used for determination of liver index, hepatic expression of glucose transporter 2 (GLUT2) as well as both inflammatory and fibrotic markers. The fat/muscle ratio, metabolic parameters, systolic blood pressure, and oxidative stress markers were also determined. Our data confirmed that the administration of morin in fructose diet rats significantly reduced the elevated systolic blood pressure. The altered levels of metabolic parameters such as blood glucose, serum insulin, serum lipid profile, and oxidative stress markers were also reversed approximately to the normal values. In addition, morin treatment decreased liver index, serum liver enzyme activities, and fat/muscle ratio. Furthermore, morin relatively up-regulated GLUT2 expression, however, down-regulated NF-kB, TNF-β, and TGF-β expressions in the hepatic tissues. Here, we revealed that morin has an exquisite effect against metabolic disorders in the experimental model through, at least in part, antioxidant, anti-inflammatory, and anti-fibrotic mechanisms.
ABSTRACT
Background@#Inguinal hernia repair is one of the most commonly performed surgical procedures. Regional blocks might provide excellent analgesia and reduce complications in the postoperative period. We aimed to compare the postoperative analgesic effect of the ultrasound-guided transversalis fascia (TF) plane block versus the transmuscular quadratus lumborum (QL) block in patients undergoing unilateral inguinal hernia repair. @*Methods@#Fifty patients enrolled in this comparative study and were randomly assigned into two equal groups. One group received an ultrasound-guided QL block.In comparison, the other group received an ultrasound-guided TF plane block. The primary outcome was the patient-assessed resting, and movement-induced pain on the numeric pain rating scale (NRS) measured at 30 minutes postoperatively. Secondary outcomes included the percentage of patients receiving rescue analgesia in the first postoperative day, ease of performance of the technique, and incidence of adverse effects. @*Results@#There were no statistically significant differences in NRS at rest and with movement between the groups over the first 24 hours postoperatively. The proportion of patients that received postoperative rescue analgesics during the first 30 minutes postoperatively was 4% (n = 1) in the QL group compared to 12% (n = 3) in the TF group. However, the mean performance time of the TF block was shorter than that of the QL block, and the performance of the TF block appeared easier technically. @*Conclusions@#The ultrasound-guided TF plane block could be as effective as the QL block in lowering pain scores and decreasing opioid consumption following nonrecurrent inguinal herniorrhaphy.
ABSTRACT
Problem: What is the role of national music videos in giving children the political concepts?
Objectives: The main objective of the study to identify the role of national music videos in giving children the political concepts through Discover the political concepts that children of the study sample known through the national music videos, Identify the aspects of benefit, which achieved by the national music videos to the children of the study sample, and Identify the relationship between the respondents Show to the national music videos and the type of their education
Sample: A field sample, which consists of 400 children from the age of [12-15] years, through the schools in the Greater Cairo and their number four preparatory schools distributed in terms of the type of education as follows [Special Language Education-Special Arabic Education-Public Experimental Education-Public Arabic Education]
Tools: Data were collected through a questionnaire for children aged [12-15] years.Statistical Methods: Simple duplicates Statistics and percentages and Chi Square Test were used to study the statistical significance of the relationship between two variables of the nominal variables
Results: The first motive of the respondents motives to National Music "Because it increases the fiduciary" at a rate of 45.1%, then came "Because they increase my knowledge about national issues" in second place at a rate of 35.5%, The correct expressions of political concepts and the forefront "Equality between people in rights and duties" came in an average 2.95, then "The feeling of love and mutual loyalty between all members of the community" with an average 2.93. The results showed that accept the zero hypothesis that says there is no statistically significant differences between the two groups of respondents, according to the type [Males-Females] in the mean scores on a measure of how giving them political concepts of national music videos
ABSTRACT
The aim of the present work is to isolate and identify Burkholderia species from different chest hospitalized patients .throat swap and sputum samples were considered. Reactivity of isolates to different antibiotics was considered using both Double Disc Synergy Test and Combined ESBL Test. Data revealed that 21/200 [10.5%] isolated from cystic flbrosis patients; samples were positive as Burkholderia isolation was more prevalent from sputum samples [55%] than throat swapping [45%]. Among the 21 bacterial isolates; 2/21[9.5%] children, 8/21[38.09%] females and 11/21[52.38%] males. The No of isolate was location related; El Sadr hospital [41%], Abbassia Chest hospital [24%], Al-Mattaria teaching hospital [21%] and health institute hospital [14%]. Also, isolation was gender related as male was more susceptible more than the other genders for infection by Burkholderia cepacia recording the highest value [52%] followed by female [38%] and children [10%]. Combined infection was recorded. Burkholderia cepacia was sensitive to Amlkacin, Gentamicin, Kanamycin, Neomycin, Ceftazidime, Ciprofloxacin and Amoxicillin/clavulanic acid, while it were resistant to; Paromomycin, Spectinomycin, Fosfomycin, Cefixime, Levofloxacin, Ofloxacin and Cefazolin. The most active antibiotic was Amoxicillin/clavulanic acid with mean diameter of inhibition zone 38.50 mm
ABSTRACT
Phylogenetic analysis of Burkholderia cepacia was achieved based on the variation of p-Lactamases production and antibacterial reactivity to different antibiotics. Sub inhibitory concentrations of augmentin down-regulates the production and/or release of exoprotein and this effect increase with increasing of the tested concentration. ESBLs was detected using double disc synergy test and combined ESBL test. Effect of reactivity of B. cepacia spp was influenced by antibiotic where Amoxicillin/ clavulanic acid showed the highest inhibitory effect and in turn clear zone dimension. Also, TEM-1 and SHV-1 genes electrophoretic pattern detected by both PFGE and RAPD. Different isolates showed a similarity to standard B. cepacia ranging from 94-95 %. Data recorded revealed the p-Lactamases genes showed a variable protein bands pattern revealing reactivity to antibiotics
ABSTRACT
Living donor hepatectomy [LDH] is now widely used to meet the need for liver grafts due to the shortage of cadaveric livers. Donor safety and perioperative anesthetic management are our major concern. The aim of our study was to compare two anesthetic techniques for management of living donor hepatectomy. After ethical committee approval and informed written consent, 20 donors ASA I physical status undergoing hepatectomy for living-relative liver transplant were allocated randomly to one of two groups. Group A where anesthesia was induced with fentanyl 2 micro g/kg and propofol 2-3 mg/kg -1, and maintained with isoflurane 0.8-1.2% and fentanyl infusion 1-2mcg/kg -1/h -1. In group B anesthesia was induced with sufentanyl 0.2mcg/kg -1, and propofol 2-3mg/kg -1, and maintained with propofol infusion 6-12 mg/kg -1/h -1, and sufentanyl infusion 0.2-0.4mcg/kg -1/h -1. Atracurium was the muscle relaxant for intubation and maintenance in both groups. There were no perioperative mortality in both groups, no significant statistical differences between both groups as regard demographic data, duration of surgery, duration of anesthesia, hospital stay, intraoperative hemodynamics, blood loss, liver function tests [PT, AST, and ALT] measured in the first, third, and seventh days postoperative. In conclusion, our study demonstrated that both anesthetic techniques were well tolerated for living donor hepatectomy, with no blood transfusion required, with short and safe discharge from PACU and short hospital stay, but with significant laboratory changes reflecting transient impairment in metabolic liver function. These procedures have proven useful as an important alternative to the cadaveric liver transplantation. Both techniques can be used as fast tract technique for living donor hepatectomy
Subject(s)
Humans , Male , Female , Living Donors , Liver Transplantation , Liver Function Tests , Heterotrophic Processes , AnesthesiaABSTRACT
Aim: this study aimed to compare the results of palliative stenting with the results of emergency surgery for patients with obstructing left-sided colorectal cancer
Methods: patients with inoperable obstructing left-sided colorectal cancer with self-expanding metallic stent [SEMS] placement [group A] or emergency surgery [group B] from June 2003 to June 2005 were included. Data on the mortality, morbidity, necessity of intensive care and hospital stay for the two groups were compared
Results: insertion of metallic stent was successful in 14 of 16 patients [87.5%]. Hospital death occurred in two patients in group A and in 6 patients in group B. The mean hospital stay was significantly shorter in [Group A]/3.3 +/- .3days versus [Group B] [15.7 +/- 0.7, p=0.0001 Table 1. The incidence of colostomy was significantly lower in [Group A] [4 patients] versus [13 patients] in [Group B], p=0.003. Twelve patients [70%] required intensive care admission after surgery, compared with only two patients [12.5%] following SEMS insertion [p=0.0001]
Conclusion: SEMS are effective in the palliation of obstructing left-sided colorectal cancer. SEMS is associated with a shorter hospital stay, less likelihood of intensive care admission and lower incidence of stoma creation, when compared with emergency surgery
ABSTRACT
Superficial cervical nerve block may reduce post-thyroidectomy pain. The aim of this study was to evaluate the influence of BSCBs as pre-emptive analgesia on patient satisfaction post- thyroidectomy surgery. Fifty adult patients were randomly allocated to one of the two groups, to receive either 20 mL isotonic sodium chloride solution [Saline group] or 20 mL bupivacaine 0.25% [Bupivacaine group] as BSCBs before induction of general anesthesia. Thyroid surgery was performed according to a standardized procedure by the same surgeon. Patients were transferred to the PACU where they stayed for 2 h, then were transferred to the ward. Morphine was administered in PACU following a standardized protocol [1-2 mg repeated every 10 minutes until the pain was controlled] if the VAS score was >/= 40 mm. Postoperative pain: was assessed by visual analogue scale [VAS], with 100 being the worst pain and 0 being no pain, by a nurse trained in pain assessment when patient is fully awake and extubated [H0], before discharge from the PACU [H+2], and every 4 h until 24 h after the end of surgery. Was evaluated the day after surgery by the anaesthetist using a 5- point verbal score [0: poor; 1: moderate; 2 good; 3: very good; 4 excellent. Total amount of morphine used in PACU and after 24hours. All adverse effects were recorded. There were no significant statistical differences between both groups as regard demographic data, duration of anesthesia and duration of surgery. The main outcome variables were pain scores [VAS], the proportion of patients given morphine at PACU and 24-h after surgery as well as the amount of morphine required. The Bupivacaine group had a smaller proportion of patients given morphine [24% vs. 72%; P = 0.0016] and [40% vs. 84%] in PACU and 24 hour after surgery respectively. Patients given BSCBs had significantly lower VAS with excellent satisfaction. We conclude that bilateral superficial cervical plexus blocks significantly reduce pain intensity and Opioids requirement in the postoperative period after thyroid surgery with excellent patient satisfaction
Subject(s)
Humans , Adult , Middle Aged , Male , Female , Cervical Plexus/drug effects , Thyroidectomy , Pain, Postoperative/therapy , Morphine/administration & dosage , Pain Measurement , Treatment OutcomeABSTRACT
Intra-peritoneal instillation of local anesthesia and morphine has been used to alleviate post-operative pain in laparoscopic surgery. Controversy exists about the efficacy of this technique. We studied 48 patients scheduled for Vertical Bypass Gastroplasy [VBG]. All of them received the same technique of general anesthesia [GA]. Patients were randomly allocated into four equal groups. They received equal volumes of the test drug instilled in the peritoneal cavity at the end of laparoscopy, 50 ml of normal saline [Group S]: 50 ml of bupivacaine 0.25% [Group B], 50 ml of bupivacaine 0.25%, plus morphine 40 mcg.kg-1 [maximum of 5 rug] Group M or [Group D] patients received the same regimen as Group M in addition, they received 75 mg intra-muscular diclophenac after induction of general anesthesia. Wound edges were infiltrated with 10 ml bupivacaine 0.25% in all patients. Morphine 25-50 mcg.kg-1 was given intravenously every 10 mm as a rescue analgesic to control postoperative pain in Post Anesthesia Care Unit [PACU]. Post operative pain was evaluated using Visual Analogue Scale [VAS]. vital signs and morphine consumption, and time to receive rescue analgesia were measured at different intervals. The incidence of post-operative complications [respiratory depression. oxygen de-saturation. arid nausea and vomiting] was recorded as well as hospital stay. There was significant decrease in VAS, HR. MBP and morphine consumption in Groups M and D when compared to Groups S and B on admission and on discharge from PACU. There were significant decrease in time to receive rescue analgesia as well as significant reduction in hospital study in Groups M and D when compared to Groups S and B. However, there was no significant difference between group S and B regarding the same parameters. The presented technique is safe and easy to use with good postoperative morphine sparing analgesia, excellent patient satisfaction and short hospital stay
Subject(s)
Humans , Adult , Male , Female , Bupivacaine/administration & dosage , Injections, Intraperitoneal , Morphine , Gastroplasty , Drug Therapy, Combination , Pain, Postoperative/therapy , Treatment Outcome , Patient Satisfaction , Length of Stay , Pain Measurement , Hemodynamics/drug effectsABSTRACT
The clinical management of verrucae is often challenging and no ideal therapy currently exists. The objective of this study was to evaluate the efficacy of pulsed dye laser [PDL] therapy in the treatment of some different types of warts. One hundred and seventeen patients [98 males and 19 females] with different types of verrucae were randomized to receive PDL [585 nm]. EMLA cream was applied to the lesion 30-45 minutes before laser therapy. Total number of sessions ranged from 1-6 sessions with an average of 1.43. Evaluation of the results of studied cases revealed that 73% of cases had good to excellent response, while 17% showed poor or no response. Verruca vulgaris and plain warts had the most excellent response, while plantar warts had the least or no response. Complications were hypo- and hyperpigmentation [3 and 2 cases, respectively], bullae formation [2 cases] and bleeding in only one case. Histopathological study after PDL therapy showed no changes immediately after laser therapy. However, thrombosis and necrosis of epidermis and dermis after 3 days were evident. Perivascular and dense infiltrate with desquamation of acanthotic and hyperkeratotic areas after 2 weeks of therapy were noticed. Revascularization of the wart blood vessels with increase in the hyperkeratosis and acanthosis occurred after one month of therapy. It was concluded that PDL is an effective and safe form of therapy for verrucae
Subject(s)
Humans , Male , Female , Laser Therapy , Postoperative Complications , Histology , Prognosis , Treatment Outcome , LasersABSTRACT
The use of self -expanding metal stents [SEMS] for palliation of malignant dysphagia is increasing. Early experience in 26 patients was included with respect to the value of stenting and management of complications encountered. SEMS were inserted in 26 patients [18 men and 8 women] of mean age 64.6 years with malignant esophageal obstruction. Data regarding stent insertion and score of dysphagia were gathered prospectively. The insertion of covered SEMS was successful in all 26 patients. Improvement in dysphagia grade by at least one grade was achieved in 96.2 percent of our patients. There were no mortality related to the procedure. Recurrent dysphagia was recorded in four cases [15.3 percent]. Two were due to stent migration and treated by another stenting. One was due to tumor overgrowth while the last was due to epithilial hyperplasia and treated by balloon dilation. Self -expanding metallic stents offer an excellent way of palliating dysphagia due to esophageal carcinoma with shorter hospital stay. It is usually successful, safe [minimal morbidity and mortality] and effective [ability to eat a near -normal diet]. Problems such as migration of the stent may be overcome by future improvements in stent design
Subject(s)
Humans , Male , Female , Esophageal Neoplasms , Stents , Treatment Outcome , RecurrenceABSTRACT
The distribution of eosinophils within the nasal cavities in 20 patients with perennial allergic rhinitis was compared to 10 healthy control subjects by taking nasal smears from 3 sites in each side of the nose: middle and inferior turbinates and post nasal space. Serum IgE levels were estimated and those above 100 IU/ml were only chosen for comparison with the level of Eosinophilia. Smears were significantly correlated with the serum IgE. Post-nasal space has been proved statistically to be the site of choice [p > 0.001] for detection of representative sampling for more accurate eosinophil expression