Synthesis and biological evaluation of some new coumarin derivatives as antimicrobial agents

A series of new 7-[2-[3-alkyl/aryl-4-arylthiazol-2[3H]-ylidene]hydrazono]propoxy]-4-methyl-2H-chromen-2-ones, [6-9a-e], was prepared by the reaction of appropriate N-alkyl/aryl-2-[1-[4-methyl-2-oxo-2H-chromen-7yloxy]propan-2-ylidene]hydrazine carbothioamides [4a-d] and phenacyl bromides [5a-e]. The purity of all new compounds was checked by TLC and elucidation of their structures was confirmed by IR, [1]H NMR, and mass spectrometry along with elemental microanalyses. All the target compounds were evaluated for their possible antimicrobial activity. Most of the tested compounds showed weak to moderate antibacterial activity against most of the bacterial strains used in comparison with gatifloxacin as a reference drug. The most active compounds were 6b, 6c, 7b, 8b, 8c, and 9c against B. cereus, E. coli and S. marcescens. Results of antifungal activity revealed that all compounds showed weak to moderate activity against S. brevicaulis, while ketoconazole as a reference drug was completely inactive. Compounds 6a, 6b, 6c, 6e and 7b were even more active than ketoconazole against F. oxysporum

comparison of ondansetrom and cyclizine as prophylaxis against postoperative nausea and vomiting in children

Nausea and vomiting is a relevant and common problem with unfavourable sequelae in children undergoing some plastic surgery procedures. There is a lack of anti-emetic trials performed in children, with only a few investigating the roles of the older anti-emetic agents such as cyclizine compared with newer ones such as ondansetron. This randomised, controlled, double-blind study examined the effectiveness of a single dose of ondansetron [0.1 mg.kg1] and cyclizine [20 mg] in the prevention of postoperative nausea and vomiting in 150 children [mean age 3.6 years] undergoing plastic genitourinary procedures. Rates of previous postoperative nausea and vomiting and motion sickness were comparable across the groups. Postoperative vomiting was significantly reduced with ondansetron prophylaxis [P= 0.006] but there was no detectable antiemetic effect with cyclizine. Furthermore, cyclizine caused pain on injection [P<0.001]