ABSTRACT
Recent studies have suggested that bacterial coinfection with Helicobacter species in patients already infected with hepatitis C virus [HCV] could be involved in the development of cirrhosis and hepatocellular carcinoma [HCC]. A retrospective study was performed in order to explore the association between Helicobacter pylori and HCV in hepatic tissue of Egyptian patients with chronic hepatitis C and hepatocellular carcinoma. The presence of Helicobacter pylori was tested by immunohistochemistry on liver samples from two groups of patients; chronic hepatitis C [group I, n = 45] and hepatocellular carcinoma [group II, n = 15]. Group I [chronic hepatitis C] involved 31 males and 14 females [male/female, 2.2:1]. Their age ranged from 27 to 58 years with a mean of 45.8 +/- 7.0 years and HCC group involved 11 males and 4 females [male/female, 2.8:1]. Their age ranged from 48 to 78 years with a mean of 60.2 +/- 10.0 years. Immunostaining revealed H. pylori microorganisms in 33/45 biopsies [73.3%] of chronic hepatitis C group and 5/15 [33.3%] of HCC group [p = 0.005]. H. pylori organisms were present in liver tissues of HCV and HCC patients with significantly higher proportion in the former. Further studies are needed to ascertain its possible role, if ever, in the pathogenesis of cirrhosis and hepatic malignancy in Egyptian patients
Subject(s)
Humans , Male , Female , Liver , Hepatitis C, Chronic , Carcinoma, Hepatocellular , ImmunohistochemistryABSTRACT
22 patients with forearm fractures was treated by a pre bend Rush nail fixation. 12 of them, the Rush nail was inserted by close method and in 10 patients, Rush nail was inserted through a localized approach. Posterior plaster slab immobilization was used for 6 weeks post- operatively. 18 of the patients sustained their fractures in a high velocity injury of motor car accidents, with associated other skeletal injuries in 5 patients, head injury in 7, abdominal or chest injuries were encountered in 5 patients. The procedure for a pre bend Rush, nailing was described in details. The patients were followed for a period sufficient for bone union. Fracture union was achieved in 20 patients, [91%]. Delayed union was wet in ulnar fracture after upward migration of Rush nail and non-union was developed in one radial fracture. According to the criteria of Anderson et al. the functional result was excellent in 14 patients, satisfactory in 6, unsatisfactory in one and failure was met in one patient with compound comminuted fracture of upper 2/3 radius. On conclusion, a pre bend Rush nail is a less invasive surgical procedure providing rotational stability with high excellent functional results, and no need for second extensive surgery for removal of the metal. It is a safe and rapid surgical procedures particularly in multiple injuried patients