Immunohistochemical analysis of P53 protein in odontogenic cysts

The p53 is a well-known tumor suppressor gene, the mutations of which are closely related to the decreased differentiation of cells. Findings of studies on immunohistochemical P53 expression in odontogenic cysts are controversial. The present study was carried-out to investigate the immunohistochemical expression of P53 protein in odontogenic cysts. Thirty paraffin blocks of diagnosed odontogenic cysts were processed to determine the immunohistochemical expression of P53 protein. Nine of the 11 odontogenic keratocysts [81.8%] expressed P53, one of three dentigerous cyst cases expressed P53, while none of the 16 radicular cysts expressed P53 protein. The findings of the present work supported the reclassification of OKC as keratocystic odontogenic tumor

Odontoma of the jaws: a clinical study of 15 cases

Odontomas are benign tumor of odontogenic origin characterized by their slow growth. They may lead to interference with eruption of its associated tooth. A retrospective study was conducted on patients with odontoma of the jaws who were treated between 1999 and 2006. Patients were analyzed with regard to the following parameters: age, gender, anatomic location, size of the lesion, histopathological classification, and associated tooth. Fifteen patients with odontomas of the jaws were included, [8 females and 7 males]. Their age ranged from 9 to 38 years [mean 21.1 years]. Of the 15 cases, 11 were complex odontoma, and 4 were compound odontoma. Whereas no site preference for complex odontoma, compound odontoma had a predilection for the anterior maxilla. Although odontoma has a limited growth potential, it should be removed because it contains various tooth formulations that can predispose to cystic change, interference with eruption of permanent teeth and cause considerable destruction of bone