ABSTRACT
The study comprises [40] women with suspected cervical intraepithelial neoplasia CIN attending the colposcopy clinic at Ain Shams Early Cancer Detection unit. All women were subjected for colposcopy. directed punch biopsy and large loop excision of the transformation zone [LLETZ]. Colposcopy was satisfactory in all women, punch biopsies were adequate for pathological examinations, the excised transformation zones were also adequate. The results of LLETZ did not agree with that of punch biopsies in [25% of cases. The pathology detected by punch biopsy was superior than LLETZ in 20% of cases. LLETZ revealed pathology greater than punch biopsy in [5%] of cases. Punch biopsy is an adequate method of diagnosis specially for smaller lesions, concerning larger, ones, it is better to have more than one biopsy or LLETZ