ABSTRACT
The objective of this study was to compare the effect of nasal wash with hypertonic saline [HS] [3.5%] versus normal saline [NS] [0.9%] on CS. Thirty patients with chronic sinusitis [CS] aged 3-16 years were studied. They were randomly divided into two treatment groups matched in age and severity of the disease. Each individual was treated with either HS or NS for four weeks. All patients were evaluated by two clinical scores [cough and nasal secretions/postnasal drip, PND] and by a radiology score at the beginning of the study and after four weeks. The results showed that the HS group was significantly improved in all scores [average +/- SD], e.g. cough score from 3.6 +/- 0.51 to 1.6 +/- 0.74, nasal secretion/PND score from 2.86 +/- 0.35 to 1.6 +/- 0.74 and radiology score from 8.06 +/- 1.28 to 2.66 +/- 1.04. The NS treatment group showed a significant improvement only in the PND score [from 2.66 +/- 0.49 to 1.53 +/- 0.83], but no significant change was reported in both cough score [from 3.53 +/- 0.52 to 3.33 +/- 0.49] and the radiology score [from 8.13 +/- 1.25 to 7.86 +/- 0.91]. It was concluded that HS nasal wash is an efficient treatment of CS
Subject(s)
Child , Nasal Lavage Fluid , Sodium ChlorideABSTRACT
Humans and rats tend to gain weight as they age; leptin is one regulator of food intake and energy expenditure. To investigate the role of aging and fasting on body weight, adiposity level and serum leptin levels, this work was undertaken in male albino rats aged 3, 24, and 30 months. Half of each age group were fasted for 48 hours and the others were allowed free access to food, after 48 hours body weight, epididymal white adipose tissue "EwAT", adiposity level and serum leptin levels were assessed in all rats. It was found that, body weight, "EWAT", adiposity level, and serum leptin levels were increased from 3 months to 24 months and were decreased from24 months to 30 months. Fasting resulted in decrease in all parameters in all age groups. These data suggest that adiposity increased with age and cannot be attributed to increased food intake or impaired leptin levels