effects of melatonin administration on some endocrine functions in rats

This study was conducted to investigate the effects of chronic oral melatonin administration in dose of 0.4 mg/kg B.W. daily for 30 days on serum TSH, T4, FSH, LH and insulin. 160 albino rats of both sexes were used, they were grouped into 16 groups, of which 8 groups were used to investigate the endocrinal effects of melatonin in both light and dark conditions. The other 8 groups were used for the same investigations under stressful condition in both light and dark as well. Half of all these groups were served as placebo controls. It was concluded that exogenous melatonin is recommended only as replacement therapy for persons sleeping in light to avoid disturbance of thyroid function especially in hyperthyroid patients. Also, melatonin has no role in counteracting the effects of acute stress on the endocrine functions related to TSH, T4, LH, FSH and insulin

Comparative study of non-steroidal anti-inflammatory drugs [NSAIDs] and their interaction with drugs affecting prostaglandins

This experimental study was carried out to evaluate the possible therapeutic and toxic effects of a more or less recent non-steroidal anti-inflammatory drug [NSAID], tenoxicam, in management of rheumatoid arthritis model in rats in comparison with indomethacin, being a standard one and piroxicam as a member of its group [oxicams]. In addition, a possible interaction between tenoxicam and both the anti- hypertensive drugs, captopril and clonidine, was also studied. This study was carried out in rats in which rheumatoid like-arthritis was induced experimentally by collagen II and complete Freund's adjuvant mixture