Epilepsy in adulthood and elderly, clinical and laboratory study

The remarkable increase in seizure onset at adulthood and elderly provokes the interest to understand not only the extent of the problem but also its clinical presentations, etiology and possible biochemical indices and oxidant parameters. For these reasons, all epileptic patients with onset at or after 40 years of age-attending the out clinics of neuropsychiatry in Assiut University Hospital within one year were fully evaluated clinically, radiologically, [especially CT scan] and biochemically [lipogram and oxidant stress]. Prevalence of epilepsy in specific age group [40 years and more] was 11/1000. Most of the patients were of low social strata and 27.3% had consanguineous marriage between parents. Generalized convulsion represents 75.6%, while partial seizures represent 18.2%. Stroke represented the most frequent etiology [60.6%] of epilepsy in this age group, followed by tumors [18.2%]. Variable% of patients with epilepsy in elderly had abnormal changes in lipids, lipoproteins and oxidant stress

Late onset involuntary movements, clinical and laboratory study

This study aimed to find the relative frequency of movement disorders, its etiology and presentation in relation to other neuropsychiatric illnesses throughout a period of 12 months. This study revealed that over a period of one year about 3100 patients aged 40 years and more with neuropsychiatric illness attended out patients clinic of neuropsychiatry, Assiut University Hospital. Ceruloplasmin and total thiol were significantly diminished in all groups of patients with movements disorders compared with the control. Lipid peroxide was significantly increased in all studied groups compared with control. These biochemical indices indicated the important role of increased oxidant stress in the etiopathogenesis of movements disorders