Physiological coagulation inhibitors [protein S, protein C and antithrombin III] in patients with recurrent venous thromboembolic disease

Protein C, protein S, and antithrombin III were evaluated in plasma of 15 patients with a history of severe recurrent thromboembolic disease and 15 normal controls to determine if plasma deficiency of any of these patients may account for observed disease. A highly significant decrease in the level of protein C and protein S was observed, [P < 0.001] while antithrombin III showed a non significant change compared with the normal control group