ABSTRACT
The aim of this work is to study the anti-inflammatory, antipyretic and analgestic activity of tramadol in animals, and evaluating these activities when combined with ketoprofen, moreover, the local anaesthetic effect of tramadol was assessed. Tramadol 4.5 mg/kg was found to be devoide of anti-inflammatory activity against edematous paws rat induced by yeast injection. While in a dose of 9 mg/kg - produced significant anti-inflammatory activity in the same test. Furthermore, tramadol 9 mg/kg exerts antipyretic effects in experimentally hyperthermic rats, but in a dose of 4.5 mg/kg did not affect the body tempreture in the same test. When tramadol 4.5 mg/kg was given in combination with ketoprofen 4.5 mg/kg produced marked and highly significant anti-inflammatory and antipyretic effect. On the otherhand tramadol at the dose levels of 6.5 and 13 mg/kg in mice produced significant increase in the hot plate [HP] latency. In the combined experiments, 6.5 mg/kg for mice given concomitently with 6.5 mg/kg ketoprofen produced marked and significant prolongation in the HP latency. The combination of tramadol and ketoprofen produced better anti-infammatory, antipyretic and analgesic effect. Also the results indicate that - tramadol has a local anaesthetic effect