Study of the thyroid gland involvement in laryngeal and hypopharyngeal cancers

Twenty case of laryngeal and hypopharyngeal cancers treated with radical surgery were studied. These were 16 males and four females with their ages ranging from 43 to 71 years. The cases included: four supraglattic cancers, five cordal cancers, one case of subglottic cancer, four cases of postcricoid cancer and one case of cancer of the pyriform fossa. All cases were squamous cell carcinomas. Serial sectioning of the thyroid gland showed its involvement in three instances: one case of postcricoid carcinoma that spread to the gland via lymphatic channels; and two cases of transglottic cancers. In one of these, tumor spread through the thyroid cartilage to involve the thyroid gland occured; while in the other case, involvement of the gland was by direct spread from the involved prelaryngeal lymph node. Total thyroidectomy is essential when resecting post-cricoid or subglottic cancers

Fine needle aspiration biopsy in the management of thyroid nodules

During a 15 month period, aspiration biopsy cytology was carried out on 54 patients presenting with solitary thyroid nodules. The cytological findings were compared with the histopathologic diagnoses in the surgically biopsied cases. The procedure showed a high accuracy in the differentiation of benign lesions from malignant ones, and in the specific diagnosis of the types of lesions. The method safe, simple and more specific than other currently available non-histologic techniques, used in thyroid nodule evaluation and management

Effects of ketotifen [Zaditen] on the allergic respiratory nasal mucosa-clinical, histopathological and histochemical study

Ketotifen [Zaditen-Wander Pharmaceutics] is an anti-allergic drug used in the prophylaxis of bronchial asthma. In this study a trial was made to verify the effect of this drug on established allergic rhinitis conditions. Its efficiency as documented by studying the clinical picture, histopathological and histochemical changes occurring in the nasal mucosa in response to its oral administration. Thirty patients with perennial allergic rhinitis were the material of this research. On the results of this trial therefore ketotifen, in a dose of 1 mg twice daily, may provide an effective form of symptomatic control for allergic rhinitis sufferers. It proved safety on prolonged administration than the other conventionally used antihistaminics