ABSTRACT
No abstract available.
Subject(s)
Delivery of Health Care , Global Health , World Health OrganizationABSTRACT
Studies show that in recent years, mental disorders have increased in various communities. Because of continuity of social sciences, study of combined socioeconomic factors can lead to important policy recommendations. The purpose of this study was to determine the effect of socioeconomic factors on mental health of Iranian people. This analytical descriptive study was performed using data from 30 provinces of Iran from 2007 to 2011 and the effect of social and economic incentives on mental health of Iranian people was evaluated. All data were obtained from Statistical Center of Iran. In this study, the suicide rate was used as an indicator [proxy] of mental health. Generalized panel with fixed effects and taking into consideration the heteroscedasticity was used to estimate coefficients. Coefficients for Iranian men and women are estimated and results are as follow: Enrolment rate 0.019 and -0.092, urbanization rate -0.34 and 0.11, unemployment rate 0.048 and 0.025, income inequality rate -0.37 and -0.06, crime rate 0.081 and 0.067 and inflation rate 0.074 and 0.022. All variables e men's enrolment rate had significant relationship with suicide rates [P<0.01]. Unemployment, crime and inflation rates and income inequality had significantly equal effect on suicide rate of men and women. The first three factors have negative and the fourth has positive effect and other factors [urbanization, divorce and enrolment rates] have distinguished effects
ABSTRACT
Background: This laboratory experiment was aimed of to investigate the antibacterial effect of Polypropylenimine-G2 [PPI-G2] and Polyamidoamine-G4 [PAMAM-G4] dendrimers on Klebsiella oxytoca, Pseudomonas aeruginosa and Proteus mirabilis.
Materials and Methods: Different concentrations of PPI-G2 and PAMAM-G4 dendrimers were inoculated onto Blank disks and were placed in Mueller-Hinton agar media. Zone of inhibition was investigated by bacterial inoculation according to the McFarland standard 0.5. Minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] of PPI-G2 and PAMAM-G4 dendrimers were determined by Micro-dilution method in nutrient broth culture.
Results: Zone of inhibition in concentration 500 MICRO SIGNg/ml of PPI-G2 dendrimers for Klebsiella oxytoca, Proteus mirabilis and Pseudomonas aeruginosa were 25, 15 and 20mm, respectively. Zone of inhibition in concentration 500 MICRO SIGNg/ml of PAMAM-G4 dendrimers for Klebsiella oxytoca, Proteus mirabilis and Pseudomonas aeruginosa were 20, 18 and 0mm, respectively. The MIC of PPI-G2 dendrimer for Klebsiella oxytoca and for Pseudomonas aeruginosa were 5 MICRO SIGNg/ml. Also, the MIC of PPI-G2 dendrimer for Proteus mirabilis was 50 MICRO SIGNg/ml. The MBC of PPI-G2 dendrimer for Klebsiella oxytoca was 50 MICRO SIGNg/ml and it was 500 MICRO SIGNg/ml for Proteus mirabilis and Pseudomonas aeruginosa. The MIC of PAMAM-G4 dendrimer attributed to Klebsiella oxytoca and Proteus mirabilis were reported 500 and 1250 MICRO SIGNg/ml, respectively. The MBC of PAMAM-G4 dendrimer belonged to Klebsiella oxytoca and Proteus mirabilis were 1250 and 2500 MICRO SIGNg/ml, respectively.
Conclusion: According to the results, PPI-G2 dendrimers can eliminate Pseudomonas aeruginosa, Klebsiella oxytoca and Proteus mirabilis effectively but PAMAM-G4 only has antibacterial effect against Klebsiella oxytoca and Proteus mirabilis. Also the antibacterial activity of PPI-G2 dendrimer is obviously better than those of PAMAM-G4. However, using dendrimers can be considered as a new approach for drinking water disinfection but it requires further wide range studies.
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CuO is one of the most important transition metal oxides due to its captivating properties. It is used in various technological applications such as high critical temperature superconductors, gas sensors, in photoconductive applications, and so on. Recently, it has been used as an antimicrobial agent against various bacterial species. Here, we synthesized CuO nanoparticles [NPs] and explored the antibacterial activity of CuO NPs preparation. Single crystalline nanoparticles of copper oxide having almost uniform particle size of 5-6 nm has been synthesized by a facile and versatile route. XRD spectra confirmed the formation of single phase CuO NPs. Transmission electron microscopy results corroborate well with XRD results. The technique employed is free from toxic solvents, organics and amines, is based on a simple reaction of copper sulfate and de-ionized water [DI], and their bactericidal effects against of Aeromonas hydrophila ATCC 7966T bacteria were investigated. Minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] with liquid culture for all of the Aeromonas hydrophila culture Medias was done. Present study confirms that Copper oxide nanoparticles have great promise as antimicrobial agent against Aeromonas hydrophila
Subject(s)
Copper , Nanoparticles , Anti-Infective AgentsABSTRACT
Dendrimers are a new class of synthetic macromolecules, which have many applications in medical sciences. This study was carried out with the purpose of investigating the antibacterial effect of polypropylenimine-G2 [PPI-G2] dendrimer on some bacterial species. In this study, the antibacterial effects of PPI-G2 dendrimer were studied by disk diffusion and microdilution method. PPI-G2 dendrimer in concentrations of 0.5, 5, 50, and 500microg/ml were inoculated onto blank disks and placed in Mueller-Hinton agar media. Zone of inhibition was investigated by bacterial inoculation according to the McFarland standard 0.5. Minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC] of PPI-G2 dendrimer in the concentrations of 0.05, 0.5, 5, 50, and 500microg/ml, were determined using microdilution method in nutrient broth media. In this study, antibacterial activity of dendrimer increased with increasing their concentration in the disk. Zone of inhibition in the concentration of 500microg/ml for E. coli, Enterobacter cloacae, Bacillus subtilis, and Staphylococcus aureus were 19, 20, 25, and 21mm, respectively. The MIC for Enterobacter cloacae, Bacillus subtilis, and Staphylococcus aureus was 5microg/ml and for E. coli was 500microg/ml. In addition, the MBC for Bacillus subtilis and Staphylococcus aurous was 50microg/ml and for E. coli and Enterobacter cloacae was 500microg/ml. The findings of this study showed that PPI-G2 dendrimer has antibacterial effects. However, use of the dendrimer for drinking water disinfection requires further and wider studies
Subject(s)
Dendrimers , Anti-Bacterial Agents , Escherichia coli , Enterobacter cloacae , Bacillus subtilis , Staphylococcus aureus , Microbial Sensitivity TestsABSTRACT
There is a limited knowledge about the morphological features of IgA nephropathy [IgAN]in the middle east region. The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory. At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system. In this survey, of 102 patients 71.6% were male. The mean age of the patients was 37.7 +/- 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2%, E: 32%, S: 67% also, T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis [P=0.003] and interstitial fibrosis/tubular atrophy frequency distribution [P=0.045], between males and females. Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents [P<0.001]. There was also significant correlation of serum creatinine with segmental glomerulosclerosis [P<0.001]. Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease. In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system
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Vermilion irregularities are common secondary deformities after cleft lip repair, regressed or resected hemangiomas, trauma and tumor surgeries. Vermilion deficiency attracts considerable attention and detracts from an otherwise excellent lip repair. Minor and moderate vermilion defects can be corrected with upper lip advancement, rotation flaps, tongue flaps or grafts. Major defects defy correction with local flaps. A technique is described for correction of large absolute tissue defects of the vermilion using Mutual Cross-Lip Musculomucosal Flaps [MCLMF] Or Ahmad-Ali's flaps. This technique was applied in eight patients with major vermilion defects secondary to hemangioma regression, neoplasia, and trauma. Reconstruction with MCLMF led to create a balanced donor and recipient lips appearance and function. There were no postoperative complications. Surgical results were satisfactory in all patients, and sufficient lip mobility with adequate bulk was maintained. One patient demonstrated minimal transient lip tightening. Use of Ahmad-Ali's flaps in selected patients resulted in successful reconstruction of severe vermilion defects
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IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. To examine the effect of IL-4 on IL-17 production and its effect in Collagen-Induced Arthritis [CIA] mice. Method: In this study, a chicken collagen-II-induced experimental arthritis [CIA] model was used in DBA/1 mice to investigate the relationship between IL-4 and IL-17 as well as other inflammatory factors. On the 38th day after the mice were induced with CIA, the expression of IL-17 and IL-4 as well as IFN-gamma and IL-13 in sera of the mice was measured by QRT-PCR and ELISA. The result of QRT-PCR analysis of IL-17 and IL-4 mRNA levels in the spleen showed that IL-17 is increased significantly at the onset of CIA in the spleen [p<0.01]. Meanwhile, IL-17 is generally reduced at the peak of CIA but IL-4 is increased significantly at this peak in the spleen [p<0.05] when the weight of the animal was taken into consideration. IL-4 can be involved in the production of IL-17 at especially the peak of CIA. These results imply that the inhibition of IL-17 may decrease the expression of IL-lp and IL-6 production which will result in the aggravation of arthritis
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The clinical effectiveness of heart valve replacement surgery has been well documented. Mechanical and homograft valves are used routinely for replacement of damaged heart valves. Homograft valves are produced in our country but we import the mechanical valves. To our knowledge the cost-effectiveness of homograft valve has not been assessed. The objective of the present study was to compare the cost-effectiveness of homograft valve replacement with mechanical valve replacement surgery. Samples were selected from 200 patients that underwent homograft and mechanical heart valve replacement surgery in Imam-Khomeini hospital [2000 - 2005]. In each group we enrolled 30 patients. Quality of life was measured using the SF-36 health survey and efficacy was measured in QALYs. For each group we calculated the price of heart valve and hospitalization charges. Finally the cost-effectiveness of each treatment modalities were summarized as costs per QALYs gained. Forty males and 20 females participated in the study. The mean score of quality of life was 66.06 [SD= 9.22] in homograft group and 57.85 [SD= 11.30] in mechanical group [P< 0.05]. The mean QALYs gained in homograft group was 0.67 more than mechanical group. The incremental cost-effectiveness ratio [ICER] revealed a cost savings of 9,604,440 IRRials for each quality-adjusted life year gained in homograft group. Despite limitation of this introductory study, we concluded that homograft valve replacement was more effective and less expensive than mechanical valve. These findings can encourage healthcare managers and policy makers to support the production of homograft valves and allocate more recourse for developing such activities