Comparison between clinical and biochemical versus interleukin 28b as a predictive factor of virological response to direct antiviral drugs without interferone in treatment of hepatitis c virus patients

Introduction: for SNP, the CC is associated with a higher SVR after DAAs/RBV therapy while, the genotype TT is a risk factor for non-response

Aim of the work: this study aimed to assess the value of SNP [rs8o99917] as a predictor of SVR

Methodology: this study was a retrospective controlled study and was performed on a total number of 15o patients who were treated by DAAs/RBV for 12 weeks and SNP was done for the all the patients. Results: CC genotype was more prevalent in SVR group than CT and TT genotypes

Conclusion: determination of SNP before starting antiviral therapy may serve as a good response predictor