Adrenergic response of isolated seminal vesicles of normal and diabetic albino rats as influenced by prior administration of separate doses of androgens and estrogens

Experimental diabetes was induced in albino rats by subtotal Pancreatectomy followed by oral glucose load. This caused marked inhibition in the seminal vesicle activity as recorded by the response to epinephrine hydrochloride. Experimentally diabetic animals were treated with separate doses of male and female sex hormones. The seminal vesicle function of diabetic animals was restored to the normal by 89.37% by using the male sex hormone and by 4.28% when the female sex hormone was administered

Role of male and female sex hormones in combination in correcting diabetes induced depression of seminal vesicle responsiveness

Experimental diabetes caused a reduction in the activity of the seminal vesicle by 46.76% of the average normal control. An increment in the seminal vesicle activity of 4.72% was observed when normal animals were treated with both male and female sex hormones in combination. The administration of the same hormones to diabetic rats improved the activity of seminal vesicle by 112.15%. In the seminal vesicles, a synergistic action between androgens and estrogens on its activity has been proved

Effect of monoamine oxidase inhibitor [MAOI] and L-dopa on the activity of isolated seminal vesicles of normal and diabetic rats in presence of insulin in vitro

In vivo treatment with MAOI and in vitro incubation of isolated seminal vesicles with insulin caused an improvement in contractile responses by 56% in diabetic animals only. Prior L-Dopa administration and insulin incubation caused an improvement in the adrenergic response of isolated seminal vesicles in normal and diabetic rats. In the latter group, the improvement reached 41.21%. The observed improvement is due to the combined actions of either insulin and MAOI or insulin and L-Dopa

Effect of male and female sex hormones on the activity of isolated seminal vesicles of normal and diabetic rats in presence of insulin in vitro

Pretreatment with sex hormones and incubation with insulin improved the adrenergic response of isolated seminal vesicles in both normal and diabetic animals. Improvement reached a value of 114.74% in normal animals and 67.01% in diabetic ones. It is clear that the administration of sex hormones had the strongest beneficial effect in diabetic animals since the increments in the seminal vesicle activity due to MAOI and L-Dopa were 56% and 41.21% respectively