ABSTRACT
Background and Aim: This study was to evaluate the effects of different concentrations of jujube seed oil on the hair follicle in BALB/c mice
Materials and Methods: In this experimental study, 40 male BALB/c mice [2.5 months of age] were used. A 4 cm[2] of the back of animal's body shaved with wax. The mice were then divided into five groups [n=8]. The first three groups received Jujube oil concentrations 5%, 10% and 15%, respectively. The fourth and fifth groups were selected as the base and sham control groups, respectively. The animals received topical treatment of jujuba seed oil for 12 day. Base and control groups received Ocerin and water respectively. After passing 12 day, back skin of animals was shaved again by wax and the treatment was repeated again for further 12 days. At 13[th] day the animals were sacrificed and samples were collected and tissue processing and staining were performed. Data were analyzed by the ANOVA and Tukey statistical tests with the 22[th] version of SPSS software
Results: This study showed that mean number of hair follicles in the skin of 5% jujuba essence treated group [37.75+/-6.6], 10% jujuba [42.75+/-8.3], 15% jujuba [41.25+/-6.2] was meaningful higher than the base [18.50+/-3.1] and sham [15+/-2.1] groups. Furthermore, we also showed that the number of hair papilla, fibroblast cells and collagen fibers were increased in the treatment groups as compared with the control groups
Conclusion: Based on our study, Jujube essential oil can have very positive effects on improving hair growth and can be used for hair losing clinical trial