ABSTRACT
Introduction: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury [SCI], and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional rehabilitation program
Methods: A case of acute penetrative SCI [gunshot wound], 40 years old, was treated with intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating Factor [G-CSF] along with rehabilitation program. The neurological outcomes as well as safety issues have been reported
Results: Assessment with American Spinal Injury Association [ASIA], showed neurological improvement, meanwhile he reported neuropathic pain, which was amenable to oral medication
Discussion: In the acute setting, combination therapy of G-CSF and intrathecal Mesenchymal Stem Cells [MSCs] was safe in our case as an adjunct to conventional rehabilitation programs. Further controlled studies are needed to find possible side effects, and establish net efficacy