ABSTRACT
Background and Aim: Due to the rapid growth of global interest in use of herbal medicine, their efficacy and safety evaluation have become important. In recent studies, internal septum of walnut fruit suggested as a hypoglycemic agent. Therefore, the present work was conducted to evaluate the effects of ethanolic extract of internal septum of walnut fruit [ISWF] on some biochemical and pathological aspects related to renal function in diabetic rats
Materials and Methods: In this experimental research 32 acute Alloxan induced diabetic and 8 healthy rats divided into 5 equal group and treated orally once per day for 1 month as fallow diabetic groups I and II received 200 and 400 mg/kg of ISWF extracts, diabetic group III received 50 mg/kg metformin and diabetic group IV and healthy group received saline 0.9% as control groups. Finaly, fasting blood glucose [FBG], 24h urine total protein [UTP], blood nitrogen urea [BUN] and plasma cratinine [Cr] were assessed biochemically and also quantitative and qualitative renal histopathological altrations for 1200 glomerulus were determined pathologically
Results: In compare to diabetic control group, the ethanolic extract of ISWF in dose independence manner significantly reduced [p
Conclusion: The ethanolic extracts of ISWF have beneficial effects on renal function in diabetic rats
ABSTRACT
Diabetic men have been claimed to have lower serum free testosterone [FT] concentrations than non-diabetic men. The aim of this study was to investigate if serum FT, luteinizing hormone [LH], and follicle stimulating hormone [FSH] concentrations are different in patients with type 2 diabetes mellitus compared with healthy men and to identify factors associated with low serum testosterone concentrations in men with type 2 diabetes. Serum FT, LH and FSH concentrations in 65 men with type 2 diabetes between 50 and 55 years compared with 65 non-diabetic men in Valye-Asr Hospital in Birjand, Iran during October 2009 to August 2010. In addition, the relationships between serum FT concentrations with LH and FSH concentrations as well as other factors including age, fast blood sugar and glycemic control [HbA1C] were investigated. Serum FT concentrations were significantly lower in type 2 diabetic patients [2.53 +/- 1.68 pg/ml] than in healthy men [4.29 +/- 2.43 pg/ml] [P < 0.001]. There were not any significant differences in LH and FSH concentrations between the two groups. There was a significant negative relationship between serum FT and HbA1C, but this relation for LH and FSH was positive and nonsignificant [P < 0.001]. Serum FT concentration is lower in type 2 diabetic patients compared with nondiabetic men suggesting further research to better understand the underlying biologic mechanisms.