ABSTRACT
Ionization radiation caused to incidence of complications in the exposed organs. In prostate radiotherapy, rectum and bladder have been radiated unwantedly and indicated some complications during and after treatment. The purpose of present study is to consider and to compare clinical complications of rectum and bladder in custom block and MLC for 3- D conformal radiotherapy, in order to determine if both treatments differ with respect to creating radiation protection, subsequently in the incidence of complications. In this respect, 72 patients with prostate cancer classified into two arms, above 60 years without the history of previous radiotherapy, hormone therapy and surgery, were selected randomly in October 2014. In one arm, patients were treated with block 3- D conformal radiotherapy, and in second arm with MLC outbound technique for 3- D radiotherapy. Rectal and bladder clinical complications were recorded before, during [at the end of 10 treatment sessions], 3 and 6 months after treatment then compared based on tables [RTOG/ LENT].Obtained results showed that patients had a significant difference in such complications as urinary frequency after 10 treatment sessions, 3 months after treatment [p<0.02 and p<0.04, respectively] Also, patients had a significant difference in regard to dysuria at the end of treatment [p<0.02]. In both arms, patients had a significant difference in constipation after 30 sessions also at the end of treatment [p<0.02, p<0.02, respectively].In comparing different grades of complications based on RTOG/ LENT tables, it was not observed a significant difference between patients' complications in both arms
ABSTRACT
Emergence of drug resistance has brought major problems in chemotherapy. Using nutrients in combination with chemotherapy could be beneficial for improvement of sensitivity of tumors to drug resistance. Soybean-derived isoflavones have been suggested as chemopreventive agents for certain types of cancer, particularly breast cancer. In this study, the synergistic effects of soy isoflavone extract in combination with docetaxel in murine 4T1 breast tumor model were investigated. In this study, mice were divided into 4 groups [15 mice per group] of control, the dietary Soy Isoflavone Extract [SIE, 100 mg/kg diet], the Docetaxel [DOCE, 10 mg/kg] injection and the combination of dietary soy isoflavone extract and intravenous docetaxel injection [DOCE+SIE]. After 3 injections of docetaxel [once a week], 7 mice were sacrificed to analyze MKI67 gene and protein expressions and the rest were monitored for diet consumption, tumor growth and survival rates. In DOCE+SIE group, diet consumption was significantly higher than DOCE group. While lifespan showed a trend towards improvement in DOCE+SIE group, no significant difference was observed among the 4 studied groups. Tumor volume was not significantly affected in treated groups. A lower but not significant MKI67 protein expression was detected in western blot in DOCE+SIE group. The mRNA expression was not significantly different among groups. The results suggest that the combination of soy isoflavone as an adjunct to docetaxel chemotherapy can be effective in improving diet consumption in breast cancer
Subject(s)
Animals, Laboratory , Glycine max , Isoflavones , Plant Extracts , Taxoids , Mice , Breast NeoplasmsABSTRACT
Physical agents such as ultraviolet or ionizing radiation and repetitive trauma have been related to the causation of cancer in humans. Much less clear is the association between exposure to radiofrequency, such as radar and microwave radiation to the development of cancer. Sporadic case reports and small series suggest that this type of radiation might lead to cancer or contribute to its evolution. The association between radiofrequency and testicular damage and cancer is unproved, but clinical and experimental data are suggestive of such possibility. In this paper we have reported three cases of seminoma in person who worked in the same place that exposed to radio frequency [RF] waves