ABSTRACT
Objective: to compare the frequency of hepatic encephalopathy [HE] in HCV cirrhotic patients with and without Diabetes Mellitus
Material and Methods: this cross sectional survey of 100 patients was conducted in all medical units of Mayo Hospital Lahore after meeting the inclusion criteria. Patients were classified as diabetic if they were on oral hypoglycemic agents or insulin or have BSF>126mg/dl and non-diabetic if they had BSF<126 mg/di. The assessment for presence or absence of hepatic encephalopathy was determined using criteria defined in operational definition. HCV LIVER CIRRHOSIS is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrosis, scare tissue and regenerative nodules. Cirrhosis was confirmed by Ultrasonography abdomen and hepatitis C was confirmed with ELISA test
Results: mean age of patient was 44.43+/-10.16 years with minimum and maximum ages 18 and 60 years respectively. Frequency of DM was determined as 34% among HCV cirrhosis patients while in 66% patients the diabetes was not seen. Hepatic encephalopathy was seen in 31 [91.2%] of diabetics and in 48[72. 7%] of non-diabetic patients. HE was not seen in 21 % of patients in which 3 were diabetics and 18 were non diabetic. In this study frequency of HE was higher in diabetic group as compared to non-diabetic group i.e. P- value=0.032
Conclusion: according to this study, frequency of Hepatic encephalopathy [HE] is significantly higher in diabetic patients as compared to non-diabetic patients i.e. P value 0.032. Frequency of HE was seen in 91.2% of the diabetic patients and in 72. 7% of non-diabetic patients