ABSTRACT
Objective: The objective of this double-blind, randomized placebo-controlled trial study evaluating efficacy and biochemical effects of optimized lisinopril lOmg [F-5] as compared to placebo in adult patients with essential hypertension. Study Design. Double-blind, randomized placebo-controlled trial Place and Duration of Study: This study was conducted at the Department of Biochemistry, University of Karachi from October 20 11 to January 2012. Materials and Methods: Patients were randomized to receive once optimized lisinopril lOmg [F-5] daily and Placebo once daily for 8 weeks and at the end of study efficacy and biochemical evaluation was done. Result: The patients treated with optimized lisinopril lOmg [F-5] alone, blood pressure reduction was lower, although significant; reaching values of 140.1 * 11.41 87.7 * 5.4 mmHg [p < 0.05 versus Placebo] by the end of eight weeks of treatment.. No significant variation of blood glucose was observed and different parameters of lipid profile were also observed during the eight weeks of treatment with antihypertensive regimen used. Thus, the drug regimens used may be considered neutral as regards glucose and plasma lipid metabolism profile because drug used at low doses. Conclusion: We can suggest that the high antihypertensive efficacy, good tolerability and no biochemical effects of the optimized Lisinopril lOmg [F-5] it is an excellent option for the treatment of hypertension in a wide range of hypertensive patients, with a high potential to reduce cardiovascular risks
ABSTRACT
Objective: This study was aimed at reviewing internal fixation in our hospital and attendant complications with a view to identifying measures necessary to improve outcome. Study Design: Retrospective study Place and Duration of Study: This study was conducted at orthopedic department of Lady Reading Hospital, Peshawar from March 20 12to February 20 14. Materials and Methods: The operation register was used to identify patients who had undergone internal fixation in the main theatre of the hospital over a Three-year period were collected and their case notes were subsequently retrieved from the medical records unit of the hospital. Data pertinent to study interests were extracted using a questionnaire Results: One hundred and fifteen patients had intemal fixation during the study period but case notes of only 100 patients could be retrieved. Most patients were males with male to female ratio of 2.3:l. The mean age of patients was 32.87 and 15.2 years and the mean duration of surgery was 20.56 hours. Plate and screws constituted the most commonly used implants. Interval between surgery and fracture union was increased by long operation time [> 2. lhrs] and occurrence of post operative complications. Conclusion: Improvement in operating facilities and choice of implants would reduce operation time and post operative complications thereby impacting positively on fracture union time