ABSTRACT
Objective: To evaluate the action of 2% lidocaine on the culture results of bronchial fluid in patients suspected of having lower respiratory tract infections
Study Design: Cross-sectional analytical study
Place and Duration of Study: Shahid Sadoughi Hospital, Yazd, Iran, from November 2014 to November 2015
Methodology: Patients suspected of lower respiratory tract infections referred to bronchoscopy unit of the Hospital were included. Those with incomplete questionnaire and bronchoscopy contraindication were excluded. Bronchial fluid was aspirated before and after local application of 2% lidocaine and cultured, according to the suspected clinical diagnosis. Finally, statistical analysis was performed using SPSS software, version 17.0. For statistical comparisons, McNemar's test was used. Level of significance was kept at p <0.05
Results: The mean age of the study population was 51.83 +/- 15.93 with a range of 25 - 80 years. Out of 130 patients, 60 patients had positive culture results. Nineteen [31.7%] cases had positive culture for tuberculosis and 41 [63.3%] cases had positive results for other bacteria before intervention that did not change after using 2% lidocaine [p=1]. In 70 [53.84%] cases, results were negative before and after use of 2% lidocaine
Conclusion: No significant difference was found between culture results before and after the use of lidocaine. Therefore, lidocaine can be used during bronchoscopy to increase patient tolerance
ABSTRACT
Background: Several reports indicate that the probiotics can increase body resistance against malignant tumors. The aim of this study is to evaluate the effect of Lactobaci-llus reuteri Persian type culture collection [PTCC] 1655 in preventing tumor growth, improving weight and survival rate in mice with breast cancer
Methods: Twenty mice, the BALB/c at six weeks age, weighing approximately 17 gram were divided into two groups. Oral administration of 500 micro liters of Lactobacillus reuteri suspension performed for the first group 14 days before tumor transplantation. The second group [control] received the same volume of phosphate buffer saline [PBS]. Then the mice had tumor transplantation surgery. Lactobacillus reuteri was prescribed in the first group in seven-day period and three-day interruption pattern. At the same time the second group [control] received PBS. This process was continued until 45 day. The tumor growth, histology and body weight were evaluated in both group and the mortality of mice was recorded
Results: In the mice transplanted tumors that had received probiotics, tumor growth decreased in comparison with control group. In this group the body weight increased [P>0/05]. In addition, the survival of these mice had significantly increased compared to control group [P=0.002]. The evaluation of tumor tissue also showed increased immune system function in mice receiving the probiotic [P>0/05]
Conclusion: Lactobacillus reuteri can improve immune system function and have an important role to help treatment of cancer