DFT and molecular docking studies on biological active acridines: the interaction with bovine serum albumin

Acridine derivatives, especially 1,8-dioxo-9-aryl-decahydroacridine represent significant scaffolds in medicinal chemistry. Given the biological properties of such products which are used in drug development, they need to have appropriate carrier. Proteins are generally used as helpful tools in drug delivery. Consequently, molecular docking between these compounds and bovine serum albumin [BSA] has been taken into account. Furthermore, in order to achieve better results, the suggested compounds have been optimized using Gaussian 03 software

Time analysis of fatal traffic accidents in Fars Province of Iran / 中华创伤杂志(英文版)

<p><b>OBJECTIVE</b>To analyze the time factor in road traffic accidents (RTAs) in Fars Province of Iran.</p><p><b>METHODS</b>This study was conducted in Fars Province, Iran from November 22, 2009 to November 21, 2011. Victims'information consisted of age, sex, death toll involving dri- vers or passengers of cars, motorcycles and pedestrians, and site of injury etc. Accidents were analyzed in relation to hour of the day, season of the year, lighting condition including sunrise, sunset, daytime and nighttime.</p><p><b>RESULTS</b>A total of 3 642 deaths (78.3% were males, and the ratio of males to females was about 3.6:1) were studied regarding their autopsy records. There was a steady increase in fatal accidents occurring at midnight to 15:59. The risk of being involved in a fatal traffic accident was higher for those injured between 4:00 to 7:59 than at other times (OR equal to 2.13, 95% CI 1.85-2.44). The greatest number of fatal RTAs took place in summer. Mortalities due to RTA during spring and summer were more pronounced at 20:00 to 23:59 and midnight to 3:59, whereas mortalities in fall and winter were more pronounced from 12:00 to 15:59.</p><p><b>CONCLUSION</b>The high mortality rate of RTA is a major public health problem in Fars Province. Our results indicate that the time is an important factor which contributes to road traffic deaths.</p>

Fatal motorcycle accidents in Fars Province, Iran: a community-based survey / 中华创伤杂志(英文版)

<p><b>OBJECTIVE</b>To identify the main characteristics of victims of motorcycle accidents in Fars Province, Iran.</p><p><b>METHODS</b>This cross-sectional study was conducted in Fars Province which has the fourth largest population of all 31 provinces in Iran from March 2009 to June 2010. We included data from all 542 recorded cases of fatalities due to motor vehicle accidents. Data were recorded from the forensic medicine registry consisting of demographic and accident-related information. Demographic information consisted of name, age, sex, status of fatal victim (motorcycle driver vs passenger) and educational level.</p><p><b>RESULTS</b>Of the 2 345 autopsy records from the forensic medicine archives, 542 (23.1%) gave the cause of death as motor vehicle accidents. Mean age of these victims was (31.4+/-6.5) years, and the male to female ratio was 28. Head injury was the most common cause of death in these victims, and overall they tended to have a low level of education. Motorcycle accidents frequently involved younger age groups (15-35 years), and head trauma related with non-use of a helmet was the most common cause of death.</p><p><b>CONCLUSIONS</b>Head injury is frequent among victims in the province we studied. This situation may be related to the victims' low socioeconomic status and little education regarding traffic laws leading to speeding and disregard of these laws along with their weak enforcement.</p>

Epidemiological characteristics of fatal pedestrian accidents in Fars Province of Iran: a community-based survey / 中华创伤杂志(英文版)

<p><b>OBJECTIVE</b>To determine the epidemiological characteristics of fatal pedestrian accidents in Fars Province of Iran.</p><p><b>METHODS</b>This cross-sectional study was conducted in Fars Province of Iran during a 29-month period from March 2009 to July 2011. The data were from the Fars Forensic Medicine Registry. In 4 923 recorded road traffic accident fatalities, 971 deaths were due to pedestrian accidents. The demographic and accident-related information were analyzed by SPSS version 11.5. P value less than 0.05 was considered significant.</p><p><b>RESULTS</b>The mean age of decedents was (47.2+/-26.2) years, ranging from 6 months to 103 years old. Males accounted for 69.8% of all deaths. Fatal accidents were most common in September; 56.1% of the fatal injuries occurred on intracity roads and 33.1% on extracity roads. Fatal head injuries were present in 60.54% of cases. Evaluation of the injury site and the cause of death found that they were significantly associated with age, interval between injury and death. Besides, the type of roads played an important role in mortality.</p><p><b>CONCLUSION</b>Although the clinical management of trauma patients has been improved in our country in the recent decade, decreasing the burden of injuries needs coordination among trauma system organizations.</p>

application of a new cyanoacrylate glue in pediatric surgery for fistula closure

Surgical glues have been used in pediatric surgery because of the fragility of tissue, and to prevent major surgeries. The present report describes our experience with using a new cyanoacrylate Glubran 2 [Viareggio, Italy] in the treatment of five cases of tracheoesophageal atresia with fistula [one fistula protection, three recurrent fistula, and one unstable patients], two cases of hypospadias, one case of vesicutanouse fistula after bladder extrophy, and one case of cloacal extrophy from January-December 2008. Three cases of recurrent tracheoesophageal atresia with fistula were treated by bronchoscpic glue injection. The other two cases benefited from glue through its ability to plug the fistula and to act as a protecting layer on anastomosis. In two cases with hypospadias excessive use of the glue caused skin necrosis, which was repaired. The wounds of cloacal extrophy were protected from nearby colostomy contamination and infection, and the vesicocutanouse fistula was closed by deepithelialization and sealing with glue. Based on the outcomes of the cases, it may be possible to suggest that Glubran 2 may be used safely in Pediatric Surgery as a sealant for the prevention and treatment of fistulas

Changing prevalence of Helicobacter pylori in south of Iran

The prevalence of Helicobacter pylori has declined rapidly in Asia. This has been shown in both seroprevalence-based and endoscopy-based studies. The present study was conducted to determine the prevalence of gastric infection caused byH. pylori in an Iranian population residing in south of Iran. A total of 522 patients [266 females and 256 males with the mean age of 44.3 +/- 13.0, range 18-83 years] underwent endoscopy in Shiraz, southern Iran. The diagnosis of H. pylori infection was established by rapid urease test, culture and gram staining and the gastric disease was confirmed by an expert pathologist. From ulcerative [n=296] and non-ulcerative [n=226] patients, 156 [52.7%] and 94 [41.6%] H. pylori strains were isolated by culture, respectively. The prevalence of H. pylori infection was significantly higher in patients aged 21-30 and >50 years [66.66% and 62.12%, respectively]. However, H. pylori was not detected in 22 patients aged < 20 years The present study revealed a significant decline in the prevalence of H pylori infection in the studied population. It seems that in parallel with better therapeutic approaches and elimination of bacteria, an improvement in the personal hygiene and living conditions of the Iranian population contribute to lower prevalence of H. pylori

Wind sock deformity in rectal atresia

Rectal atresia is a rare anorectal deformity. It usually presents with neonatal obstruction and it is often a complete membrane or severe stenosis. Windsock deformity has not been reported in rectal atresia especially, having been missed for 2 years. A 2-year-old girl reported only a severe constipation despite having a 1.5-cm anal canal in rectal examination with scanty discharge. She underwent loop colostomy and loopogram, which showed a wind sock deformity of rectum with mega colon. The patient underwent abdominoperineal pull-through with good result and follow-up. This is the first case of the wind sock deformity in rectal atresia being reported after 2 years of age