Comparative study of granisetron versus combination of granisetron with dexamethasone in the prevention of postoperative nausea and vomiting in the patients undergoing elective plastic surgical procedures in head and neck region

Postoperative nausea and vomiting is a major challenge with an incidence of 70% to 80%. This study evaluated the efficacy of Granisetron with or without Dexamethasone in reducing postoperative nausea and vomiting in patients undergoing elective plastic surgery procedures in Head and Neck region. A prospective, randomized, double blinded study of 90 patients undergoing plastic surgery procedures in Head and Neck region under general anesthesia with prophylactic Granisetron alone or combination of granisetron and dexamethasone or placebo was done. The main outcome measures were the occurrence of vomiting and severity of nausea up to 24 hours postoperatively. There was statistically significant difference in occurrence of postoperative nausea and vomiting when prophylaxis of granisetron alone or in combination with dexamethasone was given versus no prophylaxis. Although addition of dexamethasone further decreased the incidence of nausea and vomiting but the difference was not statistically significant It was concluded that in patients undergoing plastic surgery procedures in Head and Neck region, the addition of dexamethasone to granisetron decreased the incidence of postoperative nausea and vomiting up to 24 hours

Double blind placebo controlled study on "efficacy of lignocaine pretreatment in reducing pain during injection of propofol" in patients undergoing elective maxillofacial surgeries

This study was undertaken to evaluate the incidence and severity of pain on Injection of Propofol and to find the efficacy of lignocaine pretreatment in reducing such pain. 150 patients undergoing different Maxillofacial Surgeries with American Society of Anesthesiologists class 1 and 2 [ASA 1 and 2] were randomly allocated in two groups, Group A [Saline group] and Group B [Lignocaine group] who received saline and lignocaine as pretreatment respectively. Another anesthetist who was blinded to study recorded pain on a 4-point pain scale. The incidence of pain on giving Propofol was 57.33%. There was reduction of pain by 32% in the patient group who received Lignocaine pretreatment. It was concluded that lignocaine is an effective measure to decrease the incidence and severity of pain on injection of Propofol