ABSTRACT
Acute pain intensity after surgical operation is an important predictor of the chronic post-operation pain. Thus, controlling acute pain can play an important role during the convalescence of the patient after surgery. Preemptive analgesia indicates that if controlling the pain process starts before onset of the painful process, it will be more effective than after onset of the painful process. This study was designated with regard to the importance of controlling pain and special properties of celecoxibs. As a double-blind clinical trial, the study was conducted on 80 people who have undergone leg surgery. Patients were divided into two 40-member groups and were treated with 200 mg celecoxib or placebo two hours before surgery. The statistical blocks were used for randomization purposes. Both the patient and the person who was responsible for checking the pain intensity and opioid intake were not informed on the prescribed medicine. After the surgery was wrapped up, the patient's pain intensity was estimated based on Visual Analog Scale [VAS] 2, 6, 12 and 24 hours after surgery. After 24 hours, the uptake amount of the consumed opoid was recorded in the information form. The difference in VAS of patents two hours after surgery was not significant statistically [p=0.2]; while in celecoxib group it became significantly lower than placebo group in the hours 6 [p=0.038], 12 [p=0.037] and 24 [p=0.038] after surgery. Also pethidine intake has been significantly decreased [p=0.042] in celecoxib group compared to the placebo group. Taking 200 mg celecoxib two hours before operation will decrease significantly pain intensity and opoid intake after surgery
ABSTRACT
The Apgar score [Appearance, Pulse, Grimace, Activity, and Respiration] of newborn babies immediately after birth is a determining factor involved with mortality of newborns after birth. Regarding the disagreement on advantages and possible disadvantages of propofol rather thiopental in the available references, the study was triggered with the aim of analyzing effects of two mentioned drugs on babies' apgar score, mothers' nausea, vomit and time necessary for mothers' recovery. In this double-blind clinical trial, a total of 230 healthy women who were volunteered to undertake cesarean operation were selected and then divided randomly into two equal groups using statistical blocking. One group was treated by propofol while other one was treated by thiopental. The prescribed drugs for both groups were identical except the anesthesia induction drug. Babies' Apgar score 1 and 5 minutes after birth and recovery period, mothers' nausea and vomiting after operation were recorded. Apgar score I minute 1 [p=0.041] and apgar score in minute 5 [p=0.034] for propofol group were meaningfully higher than those for thiopental group. Recovery time from anesthesia was not different meaningfully in two groups [p=0.67]. Statistical analysis of nausea and vomit in both groups showed that they are lower in propofol group rather thiopental group [p=0.028]. It seems that in cesarean operations, after sufficient fluid therapy, propofol can be a proper drug to achieve anesthesia. Moreover it exerts less impact on cesarean babies' apgar and stimulates lower levels of nausea and vomiting in mothers