[Investigation of relationship between expression of lewis b antigen and helicobacter pylori induced peptic ulcer in Sari]

Background and Objectives: It has been indicated that some blood groups act as receptors for pathogens. There is a controversy over the relationship between Lewis blood group antigens and H. pylori infection which is one of the main causes of peptic ulcer. The aim of this study was to investigate the relationship between Lewis blood group antigens and H. pylori induced peptic ulcer

Material and Methods: Blood and saliva samples from 60 patients with peptic ulcer caused as a result of H. pylori infection and 44 healthy individuals [control group] were collected. Types of Lewis antigens and secretory state of subjects were determined using direct agglutination and saliva tests, respectively. In order to find the relationship between Lewis blood group antigens and H. pylori induced peptic ulcer, Chi-Square test using SPSS statistics software version 17.0 [SPSS Inc., U.S.A.] was applied

Results: Seventy two percent of the patients and sixty one percent of the healthy individuals were secretor and expressed Lewis B antigen. No significant relationship was observed between Lewis blood group antigens and H. pylori induced peptic ulcer

Conclusion: No significant correlation was found between Lewis B antigen and presence of H. pylori induced peptic ulcer. Further studies for identification of the role of other factors like Lewis X and Sialyl Lewis X in binding, colonization and virulence of H. pylori infection are recommended

[Comparison of non-HDL cholestrol level with LDL, cholesterol and other lipids markers level regarding investigation of lipoproteins disorder in hospitalizedpatients in Mazandran Heart Hospital]

Considering some restrictions of serum low density lipoprotein [LDL] as a marker for Coronary Artery Disease [CAD] risk factor and also the importance of apo B as a signinificant risk factor for CAD, measurement of non-HDL cholesterol has great value as a risk factor for CAD. Non-HDL cholesterol [total cholesterol minus HDL cholesterol] contains all lipoproteins including apo-lipoproteins. In this study, 200 hospitalized patients [100 men and 100 women] with the diagnosis of CAD, documented by coronary angiography and 100 persons with normal angiography were recruited as case and control groups, respectively. Non-HDL cholesterol non-HDL-c was compared with LDL- cholesterol as a risk factor for CAD. Measured levels of triglyceride, total cholesterol, lipoprotein atherogenic a [Lpa] and non-HDL-c were significantly higher than those in control group. HDL level was lower in patients group. Correlation analysis showed that non-HDL-c [and not LDL cholesterol] had a higher reverse correlation triglyceride level. Measurement of non-HDL-c could be a good marker in atherogenic lipoproteins. Furthermore, due to potential power of its other atherogenic lipoproteins, it cannot be measured by LDL alone

[Prevalence of positive hepatitis delta virus in patients with positive Hepatitis B surface antigen and its correlative factors in Sari]

Hepatitis Delta Virus [HDV] agent, or HDV, is a defective RNA virus that infects with HBV [Hepatitis B Virus]. 15 million people around the world are infected to HDV. There are different statistics in Iran and other countries about HDV incidence, according to accomplished studies. This study was done for determining HDV incidence in sari and considering its correlative factors. This study was done in a descriptive procedure on 167 patients. Correlative factors like demographic data and the ways of receiving disorder, history of tattoo, blood transfusion, were multi partner and IV drug abusers were considered. Diagnosing of blood Anti HDV in patients was by ELISA [Enzyme-Linked ImmunoSorbent Assay] way. We couldn't find any evidences of advantage of HDV in patients. Among 167 HBS-Ag positive subject [63 [37.7%] women and 104 [62.3%] men] were included. Average age of participants was 35.52 +/- 14.036. 2 subject had an addiction history [1.7%], 15 subject [9%] had a blood transfusion history, 4 [2.4%] were multipart and 1 [0.6%] had tattoo history and 2 [1.2%] were Prisoners previously. There wasn't any positive Anti-HDV Ab [Anti- Hepatitis Delta Virus Antibody] in studied patients. It shows that HDV is not endemic in sari

effect of folic acid supplementation in beta-thalassemia major: a randomized placebo-controlled clinical trial

Folic acid is a coenzyme for many important biochemical reactions including synthesis of purines, pyrimidines, and nucleoproteins. The recommended daily allowance of folic acid is 65 - 200 micro g/day for infants and children. The recommended dose for deficiency states is 1000 micro g/day; the effects of excess amounts of folic acid are unknown. The role of folic acid in preventing progression of arteriosclerosis is rather a new issue. Thrombotic events related to slightly elevated levels of homocystein in adults may be decreased by daily consumption of 1 mg of folic acid together with 5 - 100 mg of pyridoxine