ABSTRACT
The aim of this study was to translate and evaluate the validity and reliability of the Nepean Dyspepsia Index [NDI], as a disease-specific quality of life scale in patients with functional dyspepsia
Materials and Methods: Forward-backward translation was done. 80 patients with dyspepsia from the outpatient department of Imam Reza Hospital were assessed. Data were analyzed using SPSS software version 20 and face validity, content validity [CVR][pls spell out], construct validity [Spearman's rrho], and reliability [test-retest and Cronbach's Alpha] were evaluated
Results: CVR was between 0.80-1, which demonstrated good content validity. Test-retest reliability was good with correlation coefficient of 0.89 and intraclass correlation coefficient of 0.96. Internal consistency revealed alpha value of 0.93, which was well above the agreeable value of 0.70. These both indicate a good reliability. Spearman's correlation coefficient was 0.48. between all NDI items and subscales which indicates moderate to good construct validity.[it seems that this sentence is not complete because in this format it is meaningless]
Conclusion: This study demonstrates that the Persian translation of SF-NDI [pls spell out the highlighted part] is a valid and reliable instrument to measure health related quality of life [HRQoL] in Iranian patients with dyspepsia. It also shows that HRQoL is significantly higher in patients with high school diploma or higher educational levels
ABSTRACT
Celiac disease [CD] has an autoimmune disease in response to ingestion of foods containing gluten sausing damage to the mucosal tissue of small intestine. The disease can severely affect quality of life. This study aims to assess the relationship between behavioral disorders and quality of life [QOL] in patients with celiac disease. 87 celiac patients and 100 healthy individuals are selected and matched for age, sex and education. Patients with Celiac disease were recruited from a subspecialty clinic in Imam Reza [AS] Hospital and clinic in Ghaem in Mashhad. The control group consisted of healthy participants. Participants completed the Beck Depression Inventory, State Anxiety Inventory-Trait Spielberger, Toronto Alexithymia Questionnaire and SF-36 Quality of Life Questionnaire. Research data were analyzed by Pearson correlation and multiple regression analyses. There was no significant difference between the two groups in demographic variables. However significant differences existed between the variables of anxiety, depression and alexithymia. The patient group had higher depression and anxiety levels compared to healthy controls. Multiple regression analysis showed behavioral disorders, explains 43% of the variance in quality of life in patients with CD. Overall, the findings indicate there is a direct link between behavioral disorder and reduced quality of life of celiac patients. Psychotherapy and cognitive behavioral therapy can improve emotional patterns and cognition of celiac patients
ABSTRACT
Chronic liver disease comprises a wide range of diseases characterized by inflammation of the liver and progression of cirrhosis. This study aims to assess the relationship between behavioral disorders and quality of life in patients with liver cirrhosis. The available sampling method was used to divide participants into two groups of 100 patients and 100 healthy individuals, matched for age, sex and education. Patients with cirrhosis were recruited from a subspecialty clinic in Imam Reza [AS] Hospital in Mashhad. The control group consisted of healthy participants. Participants completed the Beck Depression Inventory, State Anxiety Inventory-Trait Spielberger, Toronto Alexithymia Questionnaire and SF-36 Quality of Life Questionnaire. Research data were analyzed by Pearson correlation and multiple regression analyses. There was no significant difference between the two groups in terms of demographic variables. However significant differences existed between the variables of anxiety, depression and alexithymia. The patient group had higher depression levels compared to healthy controls. Multiple regression analysis showed that behavioral disorders, explain 30% of the variance in quality of life in patients with liver cirrhosis. These findings suggest that behavioral disorders are associated with quality of life in patients with liver cirrhosis. These results also have important implications in the field of psychopathology, prevention, and treatment of patients with cirrhosis of the liverand IV drug abuse, respectively. The prevalence of HIV coinfection amongst patients with hepatitis B or C infections was low. However, further studies with larger populations are required
ABSTRACT
Microalbuminuria is a marker of vascular endothelial damage. In addition, it is reported that high serum levels of C-reactive protein [CRP] is a novel cardiovascular risk factor that impairs endothelial function. The aim of this study was to evaluate the relationship between microalbuminuria and elevated serum level of high-sensitivity CRP [HS-CRP] in type 2 diabetic patients. We measured serum levels of HS-CRP in 87 patients with type 2 diabetes mellitus. They were divided into a microalbuminuric group [n = 45] and those with a 24-hour urine albumin less than 30 mg/d [n = 42]. The relationship of serum HS-CRP level with albuminuria and other characteristics of the patients was assessed. Patients with microalbuminuria were significantly older and affected by diabetes mellitus longer than those without microalbuminuria. Also, their mean HS-CRP was significantly higher [4.98 +/- 1.45 mg/L versus 2.82 +/- 2.10 mg/L; P < .001]. The Pearson correlation test showed a significant correlation between HS-CRP level and urine albumin level [r = 0.43; P < .001]. The specificity and sensitivity of HS-CRP for detection of microalbuminuria in were 78.5% and 68.8%, respectively, and the positive and negative predictive values were 77.5% and 70.2%, respectively. In type 2 diabetic patients, microalbuminuria is accompanied by elevated HS-CRP, suggesting activation of inflammatory pathways in progression of renal and cardiovascular atherosclerotic disease. As an easier and cheaper test for assessment of diabetic nephropathy, we recommend further studies on HS-CRP in diabetic patients