ABSTRACT
Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of Parkinson's disease. It is reported that Foeniculum Vulgare L. can affect lactating and modulating dopaminergic system activity and antioxidant activity as well. In the present study, the effects of methanolic extract of Foeniculum Vulgare seeds on a Parkinson's disease model induced by ICV injection of 6-hydroxydopamin [6-OHDA] in female rats were investigated
Materials and Methods: In this experimental study, 60 female rats were randomly divided into 6 equal groups including saline, Parkinson's disease and Parkinson's groups which were treated by different doses of the extract. Parkinson's disease was induced by i.c.v injection of 6-OHDA. Methanolic extract of Foeniculum Vulgare seeds [100 and 200 mg/kg] was gavaged through two ways including repeated gavage [14 days before and 14 days after 6-OHDA injection] and acute gavage [once every day for 14 days after 6-OHDA injection]. The induced Parkinson`s disease was evaluated using Rotarod and Wire grasping tests on the day 14[th] after 6-OHDA injection
Results: The findings of the study demonstrated that repeated gavage of Foeniculum Vulgare extract improved motility and muscle tone in Parkinson's animals [p<0.05]. However, acute gavage of the extract had no significant effect on the performance of Parkinson's animals
Conclusion: Results of the current study showed that chronic administration of Feoniculum Vulgare extract may improve Parkinson's symptoms in female rats
ABSTRACT
Fournier gangrene is a rare, rapidly progressive, necrotizing fasciitis of the external genitalia, the perineum, or the abdominal wall that is associated with high morbidity and mortality. In this series, we describe 12 patients with Fournier gangrene who had presented to our medical center. Twelve men had been diagnosed with Fournier gangrene in Shohada-e- Tajrish hospital between March 2002 and September 2005. Their medical records were reviewed and the Fournier Gangrene Severity Index scores before and after the treatment were determined. Fifty percent of the patients were diabetic and their mean age was 58.2 ' 17.8 years. The mean delay between the onset of the disease and the admission was 4.9 days and the mortality rate was 16.6%. The median Fournier Gangrene Severity Index scores before the admission and at the time of discharge were 4.5 [range, 0 to 11] and 0 [range, 0 to 9], respectively [P = .005]. One of the patients who died had the scores of 11 and 9, respectively. Split-thickness skin graft was performed for 5 patients [41.7%]. In Fournier gangrene, a rapid diagnosis and emergent surgical intervention is crucial. The Fournier Gangrene Severity Index seems to be an excellent tool for outcome prediction