ABSTRACT
Background: A deficiency of Vitamin D not only causes poor bone mineralization but also has been implicated in many other chronic diseases. Recent studies have suggested a relevance of vitamin D to reproductive physiology. Moreover, recent evidence is establishing to support the hypothesis that vitamin D status may contribute to the development of metabolic disturbances in PCOS
Aim of the study: To investigate the relationship between Vitamin D level and polymorphisms related to metabolic disturbances particularly Insulin resistance in women with PCOS
Methods: A review of the scientific literature [PubMed Search 1960 to 2017] Pubmed, Embase and CENTRAL were searched to identify randomized controlled trials that investigated The Correlation between Depression and Folate Deficiency as the primary outcome. Identification of papers and data extraction were performed by two independent researchers. We searched for relevant trials in the Cochrane Library, MEDLINE [from 1960], Embase [from 1960], and ongoing trial databases; all searches current to October 2017
Results: Eight studies were included enrolling 1225 women; 779 patients with depression and 446 control subjects. Univariate regression analyses of the weighted means indicated a significant correlation between vitamin D and IR predictability in both PCOS and control women. However, the significance was neutralized after factoring BMI in PCOS women
Conclusion: There is a growing body of evidence suggesting an inverse association between vitamin D status and metabolic disturbances in PCOS in the current literature yet heterogeneity of the conducted studies made it difficult to come out with a solid conclusion. Nevertheless, normalization of vitamin D levels is recommended generally and especially for PCOS patients
ABSTRACT
Objectives: We aimed to assess the effect of anemia on subjective sleep quality in patients with iron deficiency anemia [IDA]
Methods: The present study is a prospective and cross-sectional study which has been carried out at King Abdulaziz hospital between November 2016 and April 2017. Fifty-two patients diagnosed with iron deficiency anemia and 40 healthy individuals, who are gender and age matched, were involved in the study. All participants were requested to fill 3 forms: a socio-demographic form [age, gender, marital status, income level and educational status], hospital anxiety and depression [HAD] scale and Pittsburgh sleep quality index [PSQI]
Results: According to the HAD scale, the average anxiety score was found 9.31+/-2.41 in patients and 7.62+/- 2.11 in controls. And, the average depression score was 7.49+/-2.08 in patients and 6.39+/-2.73 in controls. The total sleep quality score was 6.68+/-2.99 in patients and 4.27+/-1.71 in controls. There was a statistically significant difference in terms of anxiety, depression and sleep quality scores. Linear regression analysis showed no association between anxiety and depression with poor sleeping
Conclusion: IDA affects sleep quality irrespective of psychological symptoms such as depression and anxiety
ABSTRACT
Background: Intradialytic hypotension [IDH] remains the most common complication of hemodialysis [HD] with potentially devastating consequences despite the technological advances regarding the hemodialysis techniques of the last decades. The increasing number of advanced-age patients, diabetics and patients with cardiovascular comorbidities undergoing hemodialysis emphasizes the need on implementation of new IDH avoidance tactics
Aim of the work: Our work aimed to evaluate serum albumin [Alb] level and C-reactive protein level in hemodialysis patients and their correlation with dialysis-induced hypotension [DIH]
Patients and Methods: This prospective study was conducted based on data collected from HD patients treated at Aswan University Hospital, dialysis unit, in a period from 1/1/2017 to 30/5/2017. It included 40 chronic HD patients with no history of endocrine tumors, diabetes mellitus, liver failure, heart failure, or unstable coronary artery disease. Patients with hemoglobin less than 9 mg/dL, feverish patients, and patients with any source of apparent infection were excluded. The age of the patients ranged from over 18 to less than 75 years
Results: The mean value of serum albumin level in group [A] was [2.97 +/- 0.71] with the highest serum albumin was 4.4 and the lowest serum albumin was 2.1, while in Group [B] the mean value of serum albumin level was [4.53 +/- 0.74] with the highest serum albumin was 5.5 and the lowest serum albumin was 2.8. There was a significant decrease in serum albumin level in patients in group [A] who had developed hypotensive episodes during hemodialysis [ P value < 0.001], in group [A] also there were 18 patients had positive C-reactive protein [90%] and 2 patients had negative C-reactive protein [10%] with a mean value [15.67 +/- 13.27], while in group B : there were 2 patients had positive C-reactive protein level [10%] and 18 patients had negative C-reactive protein level [ 90%] with a mean value [2.07 +/- 1.48], So, there was a significant increase in C-reactive protein level in patients in group [A] who had developed hypotensive episodes during dialysis [ P value < 0.001]
Conclusion: Serum Alb. levels and high levels of CRP may predict an increased risk of DIH in regular HD patients and this was the main issue for our study, however we also found that there were some other biochemical markers, which can come in between with our two main markers, which confirm our results
Recommendations: Further studies on a larger scale of patients are needed to confirm these results
ABSTRACT
Losartan potassium, Valsartan, Telmisartan and Irbesartan are angiotensin-II-receptor antagonists [ARA II] group which used in treatment of hypertension alone or in combination with other drugs mainly Hydrochlorothiazide. RP- HPLC method was developed for the assay of three angiotensin-II-receptor antagonists [ARA-IIs] in presence of Hydrochlorothiazide. The method was performed by reversed phase high performance liquid chromatography using a mobile phase which is consisted of 0.025 M potassium dihydrogen phosphate [pH 6.0]: acetonitrile = 65:35% with detection at 220 nm on an ACE CIS column [250 mm x 4.6 mm, 5 microm] at flow rate 1.5 mL/min in an isocratic manner. The proposed method was validated according to ICH guidline in terms of linearity, accuracy, precision, robustness, limit of detection and limit of quantitation