1.
Journal of the Egyptian Medical Association [The]. 1993; 76 (1-6): 143-154
in English
| IMEMR
| ID: emr-28617
ABSTRACT
A new double layered insulin suppository was formulated in order to prolong the effect of bioavailable insulin in treating insulin dependent diabetic subjects. The enhancement of the bioavailability was also possible through the use of a new enamine derivative as a promoter. A 300 U insulin suppository [total mean 4.2 U/Kg] with biphasic insulin release action had a prolonged effect of up to 7 hours with smooth decrease of blood sugar. The insulin response after suppository administration demonstrated a significant positive correlation [r= 0.919, P< 0.001] with the plasma glucose level before administration