ABSTRACT
This work studied the effect of vitamin E as antioxidant and an oxygen free radicals scavenger on preventing and treating renal dysfunction induced by Cy-A in experimental rats. Five groups of male albino rats [ten each] were used; the first group served as controls, the second received vitamin E, the third received vitamin E prior to Cy-A treatment, the fourth received Cy-A and the fifth received Cy-A then vitamin E. The study revealed that Cy-A induced deterioration in renal function as manifested by a significant increase of plasma urea and creatinine levels as well as a significant increase of urinary excretion of creatinine, retinol binding protein [RBP] and thromboxane B2 [TxB2]. On the other hand, there was an association between the enhanced production of lipid peroxidation and increase excretion of thromboxane B2 [TxB2] and also cortical synthesis of endothelin. Treatment with vitamin E minimized the effects of Cy-A on kidney functions, especially if it was given prior to Cy-A. Vitamin E also decreased the synthesis of lipid peroxidation and endothelin by the cortical tissues and decreased the urinary excretion of thromboxane B2