Evaluation, preparation, and description of chitosan nanoparticles, as well as improving rivaroxaban bioavailability

The aim of the present study is the Evaluation, preparation, and description of chitosan nanoparticles and bioavilibility enhancement of rivaroxaban. Preparation of Rivaroxaban nanoparticles (RB-NPs) were prepared by the ionic gelation method. Different parameters were studied for evaluation, Preparation & description of nanoparticles. The results of the present study showed that the formulation F7 showed the significant results for all the selected parameter as compared to the other formulations. The formulation F1, F5, and F6 showed the highest production yield (52.5, 52.35, and 52.35% respectively) and F7 showed the significant production yield (51.85%), zeta-potential (23.63 mV), entrapment efficiency (99.87), particle size (316.12±2.14 nm) and poly disparity index (0.32). Nanoparticles are solid colloidal drug carriers ranging from 10—1000 nm in diameter and are composed of synthetic, natural or semi-synthetic polymers encapsulating the drug molecule.

Changes in the normal cellular architecture in the prostatic tissue with the increasing age

The frequency of the prostate disorders has been on the increase and disorders such as prostatitis, Benign Prostatic Hyperplasia and Prostatic Cancer have been on the rise. This study involved 60 cases which were further subdivided into various age groups. Study was based on the microscopic examination of prostatic tissue with individual of different age groups. The microscopic examination of prostatic tissue of different age groups showed that the prostate tissue in contrast to other organs shows hyperplasia instead of atrophy and that as the age increases there is more proliferation of fibro-musculo glandular tissue producing increase in the size of prostate which manifests itself in the form of Benign Hyperplasia of Prostate. In certain Unfortunate conditions there is profound increase in the glandular element progressing to latent carcinoma of prostate and then to full fledged Carcinoma. A need for urgent readressal to the patient's complaints as well as the examination can aid the physician/Surgeon to give the exact details about the possibility of cure, effective therapy, and staging and most importantly the prognosis of the patients' condition. In conclusion, there is change in the normal cellular architecture with the increasing age in the prostatic tissue