ABSTRACT
Background: It is hypothesized that migraine may be related to inflammatory bowel disease [IBD], therefore in this cross-sectional study we evaluated the prevalence of migraine in patients with IBD
Methods: In this cross-sectional study 80 patients with IBD and 80 patients without IBD referring to a private gastroenterology clinic from May to January 2014 were evaluated regarding the prevalence of migraine, severity of migraine based on Headache Impact Test [HIT-6], and habits related to headache
Results: 160 participants with the mean age of 35 years were evaluated. The prevalence of migraine in the case group was significantly higher than the control [21.3% vs. 8.8%,p=0.027]
Moreover, duration of each attack [hours] in IBD group was significantly higher than the control group [K0.001] while the duration of migraine involvement [months] and number of attacks was higher in the control group [p=0.019 and 0.048, respectively]
Headache other than migraine in the control group was significantly higher than the IBD group [p=0.00l]
Disability in the case group was more than the control group but the difference was not significant. The correlation between the severity of disability related to migraine [based on HIT-6] and severity of IBD [based on Mayo score and Crohn's disease activity index [CDAI]] was not significant [r=0.16, p=0.58]. Moreover the correlation between the duration of IBD and migraine prevalence was not significant [r=-0.14, p=Q. 19]
Conclusion: We found that the prevalence of migraine in patients with IBD is significantly more than normal population. More studies are needed to highlight the correlation between migraine and IBD
ABSTRACT
Nonalcoholic Fatty Liver Disease [NAFLD] is one of the most widespread human diseases that can impair liver function and sometimes progresses to cirrhosis. Recently NAFLD has been identified as an independent risk factor for cardiovascular disease. The aim of this study was to investigate the correlation of fatty liver disease and its sonographic severity on the resistance of the intracranial arteries. This study was a cross-sectional study of 55 patients referred from Gastroentrology clinic with diagnosis of NAFLD to Sonodoppler department of Iranian Center of Neurological Research. Pulsaltile index as a Hemodynamic parameter of Middle Cerebral [MCA] and basilar Arteries of NAFLD Patients was measured by Trans Cranial Doppler [TCD] sonography and the measurements were compared with normal values. Also the association of these indices with serum liver enzymes and sonographic grading of liver involvement was assessed. The analysis was done by SPSS 16. Frequency distribution, mean and standard deviation were used in descriptive analysis and statistical test c2to compare qualitative variables. Pulsatile Index [PI] were normal [MCA, P=0.166, Basilar, P=0.053] and there was no significant difference with relation to severity of fatty liver based on sonography findings [P=0.789], but serum liver enzyme levels were inversely correlated with basilar artery PI [P=0.014]. Considering the increase of cerebral arteries PI in advanced liver disease, absence of increase in vascular PI of patients in the present study could be attributed to the short duration of disease from diagnosis to perform TCD, lack of advanced liver involvement [absence of liver dysfunction] and the response effect to treatment before the TCD. Therefore, to assess vascular changes over time, repeating the TCD with assess other parameters such as Fibroscan and K18 factor that has more compatibility of liver function, could help to understand the pathophysiology of liver diseases and its effect on vascular resistance
ABSTRACT
Primary angiitis of the central nervous system [PACNS] is an idiopathic disorder [vasculitis] restricted to the central nervous system [CNS]. It often presents with focal neurological deficits suggesting stroke or a combination of confusion and headache. We herein report three cases with various combinations of fever, partial seizure, encephalopathy, paresis, headache and ataxia. One of them was initially treated as herpes simplex meningoencephalitis, but further investigations revealed primary angiitis. Primary angiitis of the CNS has protean manifestations and should always be considered in patients suspicious to have CNS infection or stroke, particularly who does not respond to the routine treatments. Clinical data, exclusion of differential diagnoses and typical angiography seem to be enough to justify the diagnosis in the majority of cases
Subject(s)
Humans , Female , Male , Adolescent , Adult , Cerebral Angiography , Central Nervous SystemABSTRACT
Effects of extremely low frequency magnetic fields [ELF-MF] with different intensities and frequencies has been investigated by several researchers. In most of these studies, the applied magnetic field has uniformly encountered whole brain and it has shown that changing intensity and frequency causes anomaly changes in electroencephalograms. The aim of current study was to investigate the effect of local exposure to ELF-MF with different intensities on EEG signals. Magnetic field with frequency of 10 Hz and intensity of 100, 120, 160, 200, 240, 280, 320 and 360 micro T was applied to F3 zone in 10-20 system of 3 men locally. Finally, relative power spectrum in 5 points of head in conventional frequency bands was assessed. An increase in alpha band in regions under exposure such as F3 and O1 in intensities of 100 and 360 micro T was observed. No changes in other bands such as theta band were found. It should be noted that none of the above effects was observed in closed-eye position. Regular effects due to increasing intensity of magnetic field was not observed and changing potential of EEG signals from magnetic field with intensity of 100 and 360 micro T is more than other intensities. Changing pattern of alpha band in F4, Cz, O2 and O1 was similar to exposed F3 zone and no resonance effect was observed at 10 Hz magnetic field