in vitro comparison of antimicrobial effects of curcumin-based photodynamic therapy and chlorhexidine, on aggregatibacter actinomycetemcomitans

Introduction: Considering the importance of prevention in periodontal diseases and the important role of Aggregatibacter actinomycetemcomitans in induction and progression of these diseases, the aim of the present in vitro study was to compare the antimicrobial effects of chlorhexidine digluconate [CHX], curcumin and light-emitting diode [LED] laser, on this bacterium

Methods: Antimicrobial activity of curcumin [5 mg/ml], CHX [2%], LED [120 J/cm[2]] and LED + curcumin [120 J/cm[2] + 2.5 mg/ml] against A. actinomycetemcomitans were tested in vitro, using micro-broth dilution test. One-way analysis of variance [ANOVA] and Tukey's HSD tests served for statistical analysis

Results: Regarding the minimum inhibitory concentration [MIC], CHX had a significantly lower MIC than curcumin [P<0.05]. Sorted out by bacterial growth from lowest to highest, were CHX, LED + curcumin, curcumin, and LED groups. All the differences were found to be statistically significant [P<0.05] except for the LED group

Conclusion: We conclude that curcumin is an effective substance in preventing the growth of A. actinomycetemcomitans, whose impact is reinforced when used simultaneously with photodynamic therapy [PDT]

[ comparison of osteobiol gen_oss with normal healing extraction socket in quality and quantity of bone formation for implant placement in partial edentulous patients]

The increase in the number of complex implant cases has drawn the attention of researchers toward materials having bone regeneration promoting ability. Socket preservation and bone graft are recommended to minimize bone resorption. The aim of this study was to evaluate a kind of xenograft collagenic bone [osteo biol gen_oss] in socket regeneration. This randomized clinical trial was performed in 12 cases [6 in test and 6 in control groups] with two hopeless teeth. After tooth extraction, in test group, graft material was put in sockets but in the control group the socket was healed naturally. Three months later, during implant placement the specimens from both sites were sent to a pathologist for histologic and histomorphometric evaluations. Data were analyzed using Mc Nemar and Wilcoxan sigh rank test [alpha=0.05]. There were no significant differences between two groups in foreign body reaction, inflammation, bone vitality and percentage of bone gain. Average percentage of residual graft in test site was 6.73 +/- 1.43. Osteobiol gen_oss xenograft is an appropriate biocompatible osteoconductive material that promotes bone regeneration at 3 months following socket preservation in human extraction sockets