[ effect of an endurance training period with cellular anti-aging purpose on telomerase enzyme activity in cardiac tissue and peripheral blood lymphocytes in male rats]

Introduction: The purpose of this study is to evaluate effect of moderate endurance training activity on cellular antiaging process by modulation of telomeraze enzyme content in cardiac tissue and penipheral blood eylymphocytes in male rats

Methods: Samples were rats provided by Pastear Institate of Iran. They were randomly assigned into two groups leacth composed of 8 rats

Results: 2 weeks ware allocated for adaptation to environment and changes of biological rhythm [1[st] week], and familiarity with treadmill [2[nd] week]. major protocal began after that, which includes a session of moderate daily exercise for fine days per week. Exercise continued for 16 weeks whilk the control group were sedentary. During the 1[st] eighth weeks speed of ranning on treadmill increased from 15m/min to 25m/min and reine from 15 minutes to 25 minutes progressirely, but in tensity was unchanged during the 2[nd] eighth weeks period. One day after and to the protocol, Samples were collected in fasting situation. the results showed that moderate endurance training Downloaded from jmciri.ir at 16:40 +0430 on Tuesday July 10[th] 2018 have a statistically significant effect on increasing telomerase enzyme content in cardiac tisswe [P=0/004], and lymphoeytes [p=0/004]

Conclusion: In Summany, resalts sugyested that moderate, regulaer physical activity [60-65% vozmax] have an induction effect in telomerase content and length stabilily, which in turn lead to cellular viability improvement and genomic stabilily that ploy an anti-aging role

Chondroma of falx: case report of a rare condition

Chondroma is a benign tumor which mostly occurs in extremities but also sometimes in brain. Most intracranial chondromas arise from skull base, but chondroma of falx origin is a rare circumstance. Indeed, the intracranial chondromas rise from falx is mostly in relation with syndromic disorders such as Mafucci's syndrome or Ollier's syndrome. Here, we reported a rare case of falxian intracranial chondroma in a young man who has normal physical examination and no signs of any syndromic disorder. The goal of this paper was to raise awareness about chondromas and suggest that chondroma be ruled out in any patient with masses arising from falx

Fungal granuloma of the brain in a case of chronic mucocutaneous candidiasis

Although fungal brain infections are not uncommon, intracranial granulomas due to fungi are rare. Immunodeficiency is considered to be the main predisposing factor. We have presented the case of a 21-year-old lady admitted to the emergency ward with the clinical picture of impending brain herniation. She was a known case of chronic mucocutaneous candidiasis [CMCC] since childhood and had been under oral topical nystatin treatment which she had arbitrarily discontinued for the past ten years. The patient underwent emergent craniotomy and resection of the lesion. Pathologic exam revealed its fungal granulomatous nature. Cultures documented Candida albicans as the offending pathogen. The history of immunodeficiency was a useful clue in this case. To the best of our knowledge, this was the first case of fungal granuloma of the brain in the setting of chronic mucocutaneous candidiasis