ABSTRACT
ABSTRACT Objectives: Obesity is a multifactorial disease characterized by the presence of the pro-inflammatory state associated with the development of many comorbidities, including bone turnover marker alterations. This study aimed to investigate the role of the inflammatory state on bone turnover markers in obese adolescents undergoing interdisciplinary weight loss treatment for one year. Subjects and methods: Thirty four post-pubescent obese adolescents with primary obesity, a body mass index (BMI) greater than > 95th percentile of the CDC reference growth charts, participated in the present investigation. Measurements of body composition, bone turnover markers, inflammatory biomarkers and visceral and subcutaneous fat were taken. Adolescents were submitted to one year of interdisciplinary treatment (clinical approach, physical exercise, physiotherapy intervention, nutritional and psychological counseling). Results: Reduction in body mass, body fat mass, visceral and subcutaneous fat, as well as, an increase in the body lean mass and bone mineral content was observed. An improvement in inflammatory markers was seen with an increase in adiponectin, adiponectin/leptin ratio and inteleukin-15. Moreover, a positive correlation between the adiponectin/leptin ratio and osteocalcin was demonstrated. Further, both lean and body fat mass were predictors of osteocalcin. Negative associations between leptin with osteocalcin, adiponectin with Beta CTX-collagen, and visceral fat with adiponectin were observed. Conclusions: It is possible to conclude that the inflammatory state can negatively influence the bone turnover markers in obese adolescents. In addition, the interdisciplinary weight loss treatment improved the inflammatory state and body composition in obese adolescents. Therefore, the present findings should be considered in clinical practice.
Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Osteocalcin/blood , Leptin/blood , Diet, Reducing , Adiponectin/blood , Exercise Therapy , Obesity/therapy , Biomarkers/blood , Weight Loss , Body Mass Index , Bone Density , Bone Remodeling , Combined Modality Therapy , Resistance Training , Obesity/bloodABSTRACT
A inflamação é a resposta protetora do organismo contra uma lesão celular. O mastócito representa uma célula do tecido conjuntivo responsável pelo início da reação inflamatória e cronificação do processo. O objetivo deste estudo foi analisar possíveis modificações na população de mastócitos de ratos com colite experimental alimentados com diferentes emulsões lipídicas. Quarenta ratos Wistar, divididos em 4 grupos (controle e experimentais) recebendo dieta oral com óleo de linhaça (AGn-3), óleo de soja (AGn-6) e óleo de canola (AGn-9) untados na ração 20 dias antes da indução da colite com ácido acético a 10%. Cada grupo foi, então, subdividido em dois subgrupos de cinco animais e avaliada resposta inflamatória aguda e crônica. Apesar de o número médio de mastócitos não apresentar diferença estatisticamente significante entre os grupos (p>0,05), a redução no número médio dessas células nos grupos AGn-3 e AGn-9 é clinicamente relevante. Este trabalho e a literatura pertinente levantam a possibilidade de obter-se modulação mais efetiva da inflamação com emulsões lipídicas suplementadas com AGn-3 e AGn-9.
Inflammation is the body's protective response against cell damage. The mast cell is a connective tissue cell responsible for initiating the chronic inflammatory reaction and the process. The aim of this study was to examine possible changes in the population of mast cells in rats with experimental colitis fed different lipid emulsions. Forty Wistar rats were divided into four groups (control and experimental) received an oral diet with linseed oil (GNA-3), soybean oil (AGN-6) and canola oil (AGN-9) smeared in feed 20 days before the colitis induction with acetic acid to 10%. Each group was then subdivided into two subgroups of five animals and evaluated the acute and chronic inflammatory response. Although the average number of mast cells did not show a statistically significant difference between groups (p> 0.05), the reduction in the average number of these cells in groups AGN and AGN-3-9 is clinically relevant. This study and literature raise the possibility of obtaining more effective modulation of inflammation with lipid emulsions supplemented with AGN and AGN-3-9.
La inflamación es la respuesta de protección del cuerpo contra el daño celular. La célula del mástil es una célula del tejido conjuntivo responsable de iniciar la reacción inflamatoria crónica y el proceso. El objetivo de este estudio fue examinar los posibles cambios en la población de mastocitos en ratas con colitis experimental alimentado con diferentes emulsiones de lípidos. Cuarenta ratas Wistar se dividieron en cuatro grupos (control y experimental) recibió una dieta oral con aceite de linaza (GNA-3), aceite de soja (AGN-6) y el aceite de canola (AGN-9) untado en la alimentación de 20 días antes de la colitis inducción con ácido acético al 10%. Cada grupo se dividió luego en dos subgrupos de cinco animales y evaluar la respuesta inflamatoria aguda y crónica. La mediana del número de mastocitos no mostraron una diferencia estadísticamente significativa entre los grupos (p> 0,05), la reducción en el número promedio de estas células en los grupos de AGN y AGN-3 9-es clínicamente relevante. Este estudio y la literatura plantean la posibilidad de obtener la modulación más eficaz de la inflamación con emulsiones de lípidos suplementados con AGN y AGN-3-9.