ABSTRACT
To assess the efficacy and tolerability of using high dose Furazolidone just during the first week of two different quadruple regimens in eradicating H. pylori. One-hundred sixty patients with duodenal ulcer and positive H. pylori infection were randomly allocated into two groups. Group A received [OAM-F] omeprazole [20 mg BID], amoxicillin [1gr BID], metronidazole [500mg BID] for two weeks and Furazolidone [200 mg BID] just during the first week. Patients in group B received [OAB-F] omeprazole [20 mg BID], amoxicillin [1 gr BID], bismuth subcitrate [240 mg BID] for two weeks and Furazolidone [200 mg BID] in the first week. The eradication rates by per-protocol and intention-to-treat analyses were 86.36% and 80% in group A and 90.27% and 86.3% in group B, respectively. Severe side effects of the drugs were more prevalent in group A compared with group B [12.8% against 2.5%]. One-week Furazolidone combined with two-week Omeprazole, amoxicillin and bismuth subcitrate is a safe and cost effective regimen to eradicate of H pylori infection in Iran