ABSTRACT
Bakground: Chronic liver damage is a worldwide common pathology, characterised by an inflammatory and fibrotic process that leads to a progressive evolution from chronic hepatitis to cirrhosis and hepatocellular carcinoma. A major role of fats and oxidative stress has been recently demonstrated in the pathogenesis of liver diseases. It was a newly introduced plant from Mexico. In India, it is grown in gardens, especially in Kerala, where the fresh leaves are eaten raw by diabetic people
Objective: This work aimed to study the effect of phyllanthus and costus aqueous extracts on CcL4 intoxicated rats
Material and methods: Thiry mature male albino rats weighing 150 +/- 5g were obtained from Laboratory of Animal Colony, Helwan, Egypt. Rats were divided into 6 equal groups [n=5 rats each]; one group was kept as a control negative, while the other 5 groups were injected subcutancosly [s/c] by carbon tetrachloride [CcL4] in parrafin oil 50% V/V [2ml / kg b.wt.] twice a week for two weeks for liver intoxication then, one group of them was left as control positive group [C +ve] while the rest four groups were given orally two doses [250 and 500 mg/kg] of phyllanthus and costus aqueous extracts [250 mg/kg and 500 mg/kg for the group. At the end of experimental period [45 days], blood samples were collected for serum separation to determine serum liver enzymes [AST, ALT and ALP], total cholesterol, triglycerides, atherosclerosis index, lipoprotein fraction [HDLc, LDLc and VLDLc], kidney function[Creatinine, Urea and Uric acid] and histopathological examination for the liver
Results: The obtained results demonstrated that phyllanthus and costus aqueous extracts caused significant improvement in liver enzymes, lipid profiles and kidney functions in CcL4 intoxicated rats
Conclusion: According to the results, phyllanthus and costus aqueous extracts could be tried on intoxicated patieats to improve liver and kidney function