Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>In this study, the ameliorative effects of gold nanoparticles (gold NP) on the renal tissue damage in Schistosoma mansoni (S. mansoni)-infected mice was investigated.</p><p><b>METHODS</b>High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into S. mansoni-infected mice.</p><p><b>RESULTS</b>The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-1, NGAL, MCP-1, and TGF-β mRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by S. Mansoni infection.</p><p><b>CONCLUSION</b>The curative effect of gold NP against renal toxicity in S. mansoni-infected mice is associated with their role as free radical scavengers.</p>

Zoonotic dicrocoeliasis dendriticum in a farmer's family at Giza governorate, Egypt

Dicrocoeliasis [Lancet liver fluke disease] is caused by Dicrocoelium dendriti-cum, a trematode living in bile ducts of sheep, cattle and other mammals including man. Human infection is asymptomatic or mild to moderately severe, but being sporadic or rarely reported. This paper reported zoonotic dicrocoeliasis dendriticum among a farmer's family and his domestic animals. The father and mother were successfully treated with Triclabendazole and the children and animals were successfully treated with Mira-zid and Oleo-resin solution of Commiphora molmol respectively

impact of three anopheline mosquito species in Toshka, on the introduction of chloroquine / resistant P. Falciparum to Egypt

Malaria still tops the prevalent human arthropod-borne diseases. In Egypt, sporadic cases of human malaria were reported with a focus in Al-Fayoum. Besides, many Egyptian Anopheles species were reported allover which are either malaria vectors or incriminated ones. This study recorded An. multicolor, An. sergentii, and An. algeriensis in Toshka. Many authors reported that A. sergentii is a malaria-vector and A. multicolor is a suspected vector. Consquently, the endemicity of Chloroquine resistant Plasmodium falciparum on the Egyptian-Sudanese border pave the way for malignant malaria transmission particularly among travelers returning back from Sudan

Corvus R. ruficollis [desert or brown necked raven]: a reservoir host for zoonotic parasites in Egypt

Egypt includes many desert and rural areas. The small uptown fertile areas are placed under illegal enormous pressure of existing resources, where intensive agricultural practices are performed, in combination with high population densities. The brown necked ravens [Corvus ruficollis] are attracted in huge numbers to such areas. The birds are omnivorous, very aggressive pest and seriously affect human welfare. The study focused on zoonotic role of ravens