ABSTRACT
Psoriasis is a chronic dermatosis characterized by the presence of heavy neutrophilic infiltrate in both the dermis and epidermis, together with elongated tortuous blood vessels in dermal papillae. Rheumatoid arthritis [RA] is a chronic inflammatory disease characterized by neovascularization and inflammatory cell infiltration within the synovium with associated synoviocyte hyperplasia. Several factors are found to be behind such a type of inflammation, including PIGF. Recognition of how this factor involved in the pathogenesis of psoriasis and RA may be of great help in the development of a new specific therapeutic modality of these disease. Is to study the role of PIGF [serum and synovial] as one of the factors underlying the pathogenesis of psoriasis and rheumatoid arthritis and its correlation with disease severity, duration and activity. Twenty eight RA patients were included in this study, diagnosed according to ACR classification. Forty psoriatic patients were also included in this study, examination and determination of the disease severity using PASI score were done. Measurement of the serum and synovial fluid [SF]PIGF level using ELISA technique was performed and correlation of disease duration and severity with its level was also done. We found that s.PIGF was high in serum of 64% of RA pts and in all synovial fluid samples. There is apositive correlation between the disease severity and its level ,however the correlation between the disease duration and the serum level of P1GF was insignificant.There is a positive correlation between serum and synovial PIGF in rheumatic patients. Serum PIGF [s.PIGF] was high in 92.5% of psoriatic patients and was significantly high in those with severe and moderate disease activity in comparison to those of mild activity and control group. s.PIGF was highly significant correlated with lesion severity. The prevalence of PsA is 35% of psoriatic pts,[male to female 5/2]. 8 patients have oligoarthritis, 6 patient have polyarthritis and DIP involvement .2 of them have spondyloarthropathy. PIGF has a role in the pathogenesis in rheumatoid arthritis and skin lesion of psoriasis and psoriatic arthritis