ABSTRACT
Objective: To evaluate inflammatory markers in full term neonates with unconjugated hyper-bilinibinemia. Design: Prospective case control study. This study was done in the department of pediatrics screening clinic, Al-Galaa Teaching Hospital, in Cairo, Egypt from October 2012 to June 2014
Subjects and Methods: The study was done on seventy five full term neonates their age ranged from 3 to 6 days after birth, fifty with unconjugated hyperbilirubinemia compaired to twintyfive normal neonates as control group with matched age and sex. All neonates were subjected to history taking [including gestational age, postnatal age] and clinical examination, anthropometric data, and laboratory investigations including complete blood count, CRP and inflammatory markers TNF-a and ILIp concentration by ELISA
Results: Regarding total bilirubin level in unconjugated hyperbilirubinemia neonates, there was statistically significant to inflammatory markers TNF-a and IL-Ip[p-value was <0.001]. The same finding were also it was found that both inflammatory markers IL-lp and TNF-a showed statistically significant positive correlation with breast feeding p-value was 0.021 for IL-lp and 0.003 for TNF-a respectively. Inflammatory markers IL-lp and TNF-a increasing levels showed positive correlation with neurological examination [Lethargy or irritability, p-value were 0.01 1 for IL-p and 0.046 for TNF-a respectively
Conclusion: Inflammatory markers IL-lp and TNF-a levels increased in neonatal unconjugated hyperbilirubinemia. Inflammatory markers IL-lp and TNF-a was found correlation between neurological examination. Recommendations: Further studies on larger sample size [are advised to verify the diagnostic and prognostic value of inflammatory markers in neonatal unconjugated hyperbilirubinemia which may help also in treatment. Key words: Inflammatory markers, IL-lp and TNF-a, neonatal unconjugated hyperbilirubinemia, Bilirubin and neurological dysfunction