ABSTRACT
Abstract Objective: Transcatheter aortic valve replacement has been an alternative to invasive treatment for symptomatic severe aortic stenosis in high risk patients. The primary endpoint was 30-day and 1-year mortality from any cause. Secondary endpoints were to compare the clinical and echocardiographic variation pre-and post- transcatheter aortic valve replacement, and the occurrence of complications throughout a 4-year follow-up period. Methods: This prospective cohort, nestled to a multicenter study (Registro Brasileiro de Implante de Bioprótese por Cateter), describes the experience of a public tertiary center in transcatheter aortic valve replacement. All patients who underwent this procedure between October 2011 and February 2016 were included. Results: Fifty-eight patients underwent transcatheter aortic valve replacement. The 30-day all-cause mortality was 5.2% (n=3) and after 1 year was 17.2% (n=10). A significant improvement in New York Heart Association functional classification was observed when comparing pre-and post- transcatheter aortic valve replacement (III or IV 84.4% versus 5.8%; P<0.001). A decline in peak was observed (P<0.001) and mean (P<0.001) systolic transaortic gradient. The results of peak and mean post-implant transaortic gradient were sustained after one year (P=0.29 and P=0.36, respectively). Left ventricular ejection fraction did not change significantly during follow-up (P=0.41). The most frequent complications were bleeding (28.9%), the need for permanent pacemaker (27.6%) and acute renal injury (20.6%). Conclusion: Mortality and complications in this study were consistent with worldwide experience. Transcatheter aortic valve replacement had positive clinical and hemodynamic results, when comparing pre-and post-procedure, and the hemodynamic profile of the prosthesis was sustained throughout follow-up.
Subject(s)
Humans , Male , Female , Aged , Aged, 80 and over , Aortic Valve Stenosis/surgery , Transcatheter Aortic Valve Replacement/methods , Severity of Illness Index , Brazil , Heart Valve Prosthesis/adverse effects , Echocardiography , Prospective Studies , Risk Factors , Treatment Outcome , Transcatheter Aortic Valve Replacement/adverse effectsABSTRACT
Abstract Objective: To assess heart rhythm and predictive factors associated with sinus rhythm after one year in patients with rheumatic valve disease undergoing concomitant surgical treatment of atrial fibrillation. Operative mortality, survival and occurrence of stroke after one year were also evaluated. Methods: Retrospective longitudinal observational study of 103 patients undergoing rheumatic mitral valve surgery and ablation of atrial fibrillation using uni- or bipolar radiofrequency between January 2013 and December 2014. Age, gender, functional class (NYHA), type of atrial fibrillation, EuroSCORE, duration of atrial fibrillation, stroke, left atrial size, left ventricular ejection fraction, cardiopulmonary bypass time, myocardial ischemia time and type of radiofrequency were investigated. Results: After one year, 66.3% of patients were in sinus rhythm. Sinus rhythm at hospital discharge, lower left atrial size in the preoperative period and bipolar radiofrequency were associated with a greater chance of sinus rhythm after one year. Operative mortality was 7.7%. Survival rate after one year was 92.3% and occurrence of stroke was 1%. Conclusion: Atrial fibrillation ablation surgery with surgical approach of rheumatic mitral valve resulted in 63.1% patients in sinus rhythm after one year. Discharge from hospital in sinus rhythm was a predictor of maintenance of this rhythm. Increased left atrium and use of unipolar radiofrequency were associated with lower chance of sinus rhythm. Operative mortality rate of 7.7% and survival and stroke-free survival contribute to excellent care results for this approach.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Young Adult , Rheumatic Heart Disease/surgery , Atrial Fibrillation/surgery , Heart Valve Diseases/surgery , Rheumatic Heart Disease/physiopathology , Rheumatic Heart Disease/mortality , Atrial Fibrillation/physiopathology , Atrial Fibrillation/mortality , Cardiopulmonary Bypass , Sex Factors , Multivariate Analysis , Reproducibility of Results , Retrospective Studies , Age Factors , Treatment Outcome , Catheter Ablation/methods , Catheter Ablation/mortality , Risk Assessment/methods , Kaplan-Meier Estimate , Heart Rate/physiology , Heart Valve Diseases/physiopathology , Heart Valve Diseases/mortality , Mitral Valve/surgery , Mitral Valve/physiopathologyABSTRACT
FUNDAMENTO: A prevalência da fibrilação atrial, os gastos com o sistema de saúde e a elevada morbidade e mortalidade associadas a ela, têm justificado a procura por novas abordagens terapêuticas. OBJETIVO: Avaliar a reprodutibilidade da técnica cirúrgica, a segurança e os resultados inicias da cirurgia vídeo-assistida para a ablação da fibrilação atrial isolada com radiofrequência bipolar. MÉTODOS: Dez pacientes (90 por cento homens) com fibrilação atrial (50 por cento paroxística) sintomática e refratária à terapia medicamentosa, sem doença cardíaca que requeresse cirurgia concomitante, foram submetidos à ablação da arritmia guiada por toracoscopia, no período de maio de 2007 a maio de 2008. Variáveis clínicas, laboratoriais e de imagem foram prospectivamente coletadas antes, durante e no seguimento pós-operatório. RESULTADOS: A cirurgia foi realizada conforme o planejado em todos os pacientes. Não houve lesão iatrogênica de estruturas intratorácicas ou óbitos. No seguimento médio de seis meses, 80 por cento dos pacientes estão livres de fibrilação atrial. Houve melhora significativa dos sintomas de insuficiência cardíaca classe funcional New York Heart Association (2,4 ± 0,5 para 1,6 ± 0,7; p = 0,011). Não houve evidência de estenose de veias pulmonares à angiotomografia, nesta série. CONCLUSÃO: A cirurgia vídeo-assistida para o tratamento da fibrilação atrial é reprodutível e segura. Há melhora evolutiva dos sintomas de insuficiência cardíaca após a cirurgia.
BACKGROUND: The prevalence of atrial fibrillation, expenses with the healthcare system and the associated high morbidity and mortality have justified the search for new therapeutic approaches. OBJECTIVE: To evaluate the reproducibility of the surgical technique, its safety and the initial outcome of the video-assisted surgery for the isolated atrial fibrillation ablation with bipolar radiofrequency. METHODS: Ten patients (90 percent men) with symptomatic atrial fibrillation (50 percent paroxystic type) that was refractory to drug therapy, with no heart disease that required concomitant surgical treatment, were submitted to arrhythmia ablation guided by thoracoscopy from May 2007 to May 2008. Clinical, laboratory and image variables were prospectively collected before, during surgery and at the postoperative follow-up. RESULTS: The surgery was carried out as planned in all patients. There was no intra-thoracic structure iatrogenic lesion or deaths. At the mean 6-month follow-up, 80 percent of the patients were free of atrial fibrillation. There was a significant improvement in the symptoms of New York Heart Association Functional Class heart failure (2.4 ± 0.5 to 1.6 ± 0.7; p=0.011). There was no evidence of pulmonary vein stenosis at the angiotomography in this series. CONCLUSION: The video-assisted surgery for the treatment of atrial fibrillation is reproducible and safe. There is a heart failure symptom evolution improvement after the surgery.
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Atrial Fibrillation/surgery , Catheter Ablation/methods , Thoracic Surgery, Video-Assisted , Catheter Ablation/adverse effects , Epidemiologic Methods , Treatment OutcomeABSTRACT
FUNDAMENTO: A oxigenação por membrana extracorpórea (ECMO) em recém-nascidos e crianças tem resultados excelentes. A experiência em adultos é mais modesta e os resultados imediatos são inferiores. Entretanto, a sobrevida em cinco anos de pacientes que sobrevivem a esse método é bastante promissora. Não há relato na literatura brasileira de experiências com esse sistema nesse contexto. OBJETIVO: Relatar a experiência com o uso da oxigenação por membrana extracorpórea no adulto que se apresenta em choque cardiogênico agudo e refratário. MÉTODOS: Análise retrospectiva de prontuários médicos de pacientes submetidos a implante do sistema de oxigenação por membrana extracorpórea para a assistência circulatória no choque cardiogênico agudo e refratário. RESULTADOS: Onze pacientes (63,5 anos; 45,5 por cento homens) foram considerados para análise no período de 2005 a 2007. O tempo médio de suporte circulatório foi de 77 horas (10-240h) e cinco pacientes estavam vivos em 30 dias (45,5 por cento). Dois pacientes foram subseqüentemente submetidos a implante de assistência circulatória prolongada após um período de ressuscitação em ECMO, um dos quais foi submetido ao transplante cardíaco. As causas de morte durante a assistência com ECMO (seis pacientes) incluíram falência multiorgânica (66,6 por cento) ou sangramento refratário (33,4 por cento). CONCLUSÃO: O sistema ECMO é uma opção de assistência circulatória temporária para pacientes adultos com falência cardíaca aguda refratária, podendo ser utilizado como ponte para a recuperação ou com o intuito de selecionar candidatos à assistência circulatória prolongada (ponte para a ponte).
BACKGROUND: The extracorporeal membrane oxygenation (ECMO) has been used in the neonatal and childhood periods with excellent results. The adult experience has been modest with inferior immediate results. The intermediate survival, however, has been promising. We have been using the extracorporeal membrane oxygenation for temporary mechanical circulatory support of adults that present with acute refractory cardiogenic shock in our institution. There is no other published experience of the use of this system in this scenario in Brazil. OBJECTIVE: To describe our experience with the use of the extracorporeal membrane oxygenation for circulatory support in adults. METHODS: Retrospective analysis of the medical files of patients submitted to the implant of extracorporeal membrane oxygenation system for circulatory assistance in acute and refractory cardiogenic shock. RESULTS: Eleven patients (63,5yo; 45,5 percentmale) were considered for analysis from 2005 to 2007. Median support time was 77 hours (10-240h) and 5 patients have survived 30 days (45,5 percent). Two patients were subsequently submitted to prolonged paracorporeal circulatory assistance. Mortality on ECMO (6 patients) was due to multiple organ failure (66,6 percent) and refractory bleeding (33,4 percent). CONCLUSION: ECMO system is an option to be used in acute refractory cardiogenic shock as a bridge to recovery or selecting patients that might benefit from prolonged paracorporeal assist devices (bridge to bridge).
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Extracorporeal Membrane Oxygenation/standards , Heart-Assist Devices , Heart Failure/therapy , Shock, Cardiogenic/therapy , Brazil/epidemiology , Cardiopulmonary Resuscitation/methods , Cardiopulmonary Resuscitation/standards , Extracorporeal Membrane Oxygenation/mortality , Hospital Mortality , Heart Diseases/surgery , Multiple Organ Failure/therapy , Postoperative Complications/mortality , Retrospective Studies , Survival Rate , Shock, Cardiogenic/mortalityABSTRACT
Objetivo: Avaliar a aplicabilidade, segurança e resultados iniciais da toracotomia minimamente invasiva para ligadura do canal arterial em prematuros. Métodos: Entre outubro de 1991 e julho de 2003, 273 prematuros e prematuros extremos foram submetidos à ligadura cirúrgica do canal arterial por toracotomia miopreservadora, com anestesia geral, em UTI neonatal...
Subject(s)
Humans , Male , Infant, Newborn , Ductus Arteriosus, Patent , Heart Defects, Congenital , Infant, Premature , Retrospective Studies , ThoracotomyABSTRACT
A ruptura da parede livre do ventrículo esquerdo é uma complicação potencialmente fatal e de tratamento essencialmente cirúrgico. A correção cirúrgica é o tratamento de escolha, mas o manejo pré-operatório e as técnicas de correção ainda não estão claramente definidos, sendo determinados conforme as condições clínicas do paciente. Há carência na literatura de grandes séries envolvendo este tipo de afecção e os relatos são baseados nas experiências individuais, com pequeno número de pacientes. São apresentados dois casos de ruptura subaguda da parede livre do ventrículo esquerdo como complicação da evolução do infarto agudo do miocárdio. Discute-se a abordagem cirúrgica completa, com revascularização miocárdica concomitante e a utilização de circulação extracorpórea. A opção de correção do defeito por meio da sutura epicárdica com retalho de pericárdio bovino e a revascularização completa do miocárdio, sobretudo sem circulação extracorpórea, parece ser a melhor estratégia para um grupo de pacientes que apresentam ruptura subaguda da parede livre do ventrículo esquerdo pós-infarto agudo do miocárdio.